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Tbio
TPRN
Taperin

Protein Summary
Description
This locus encodes a sensory epithelial protein. It was defined by linkage analysis in three Pakistani families to lie between D9S1818 (centromeric) and D9SH6 (telomeric). Mutations at this locus have been associated with autosomal recessive deafness. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409012
  • ENSP00000387100
  • ENSG00000176058

Symbol
  • C9orf75
  • DFNB79
  • C9orf75
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
transcription factor binding site profile
0.69
tissue sample
0.63
cell line
0.54
histone modification site profile
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.08   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.08   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  1
Score:  0.241
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999999
p_ni:  1e-9
Score:  0.335
Data Source:  BioPlex,STRINGDB
CLIC5
Tbio
Family:  IC
Novelty:  0.05504841
p_int:  0.999999932
p_ni:  6.8e-8
Score:  0.961
Data Source:  BioPlex,STRINGDB
CLIC1
Tbio
Family:  IC
Novelty:  0.00622691
p_int:  0.999999581
p_ni:  4.19e-7
Score:  0.321
Data Source:  BioPlex,STRINGDB
CLIC4
Tbio
Family:  IC
Novelty:  0.01088335
p_int:  0.999998902
p_ni:  0.000001098
Score:  0.869
Data Source:  BioPlex,STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
p_int:  0.954664761
p_ni:  0.045335239
Score:  0.86
Data Source:  BioPlex,STRINGDB
CAMK2D
Tchem
Family:  Kinase
Novelty:  0.02326864
p_int:  0.899421845
p_ni:  0.099049435
p_wrong:  0.00152872
Data Source:  BioPlex
TSPEAR
Tbio
Novelty:  0.15908638
Score:  0.87
Data Source:  STRINGDB
SMPX
Tbio
Novelty:  0.05084864
Score:  0.861
Data Source:  STRINGDB
CEACAM16
Tbio
Novelty:  0.11153655
Score:  0.829
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
4
5
89.9
creatinine measurement
2
4
5
81.6
blood protein measurement
1
1
1
78.5
reticulocyte measurement
3
1
3
72.7
reticulocyte count
6
1
6
70.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
89.9
creatinine measurement
5
81.6
blood protein measurement
1
78.5
reticulocyte measurement
3
72.7
reticulocyte count
6
70.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taperin
VGNC:4887
736109
Mouse
MGI:2139535
97031
Rat
RGD:1562935
499749
Horse
taperin
VGNC:24446
100146716
Opossum
taperin
100023406
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taperin
Mouse
Rat
Horse
taperin
Opossum
taperin
Publication Statistics
PubMed Score 24.08
PubMed score by year
PubTator Score 4.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title