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Tbio
TPRKB
EKC/KEOPS complex subunit TPRKB

Protein Summary
Description
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:28805828). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:28805828). TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (PubMed:22912744, PubMed:28805828).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272424
  • ENSP00000272424
  • ENSG00000144034
  • ENST00000318190
  • ENSP00000325398
  • ENST00000409716
  • ENSP00000386936

Symbol
  • CGI121
  • GAMOS5
  • CGI-121
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.92
transcription factor binding site profile
0.84
virus perturbation
0.79
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
OSGEP
Tbio
Family:  Enzyme
Novelty:  0.0106198
p_int:  0.999995848
p_ni:  0.000004152
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
LAGE3
Tdark
Novelty:  0.02099961
p_int:  0.999995513
p_ni:  0.000004484
p_wrong:  3e-9
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
TP53RK
Tbio
Family:  Kinase
Novelty:  0.04302252
p_int:  0.999936474
p_ni:  0.000063526
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NUP43
Tbio
Novelty:  0.11571309
p_int:  0.999917847
p_ni:  0.000082153
Score:  0.757
Data Source:  BioPlex,STRINGDB
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.996480736
p_ni:  0.003519263
p_wrong:  1e-9
Data Source:  BioPlex
CCDC28A
Tdark
Novelty:  0.47441753
p_int:  0.989632758
p_ni:  0.00913304
p_wrong:  0.001234202
Data Source:  BioPlex
MBIP
Tbio
Novelty:  0.05807454
p_int:  0.987503681
p_ni:  0.012485966
p_wrong:  0.000010353
Score:  0.656
Data Source:  BioPlex,STRINGDB
COMMD10
Tbio
Novelty:  0.29057641
p_int:  0.88874641
p_ni:  0.087364065
p_wrong:  0.023889526
Score:  0.718
Data Source:  BioPlex,STRINGDB
GATD1
Tdark
Family:  Enzyme
Novelty:  0.40291197
p_int:  0.76966542
p_ni:  0.230333258
p_wrong:  0.000001322
Data Source:  BioPlex
GON7
Tdark
Novelty:  0.21994743
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
2
4
5
98.5
blood metabolite measurement
3
3
7
98.2
serum metabolite measurement
3
5
7
98.1
glomerular filtration rate
5
4
4
10.3
97.6
hydroxy-leucine measurement
1
1
1
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
5
98.5
blood metabolite measurement
7
98.2
serum metabolite measurement
7
98.1
glomerular filtration rate
4
10.3
97.6
hydroxy-leucine measurement
1
75.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TP53RK binding protein
VGNC:10794
739292
Macaque
TP53RK binding protein
707023
Mouse
MGI:1917036
69786
Rat
RGD:9395731
103690067
Dog
TP53RK binding protein
VGNC:47754
475794
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TP53RK binding protein
Macaque
TP53RK binding protein
Mouse
Rat
Dog
TP53RK binding protein
Publication Statistics
PubMed Score 9.90
PubMed score by year
PubTator Score 3.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title