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Tbio
TPRA1
Transmembrane protein adipocyte-associated 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296210
  • ENSP00000296210
  • ENSG00000163870
  • ENST00000355552
  • ENSP00000347748
  • ENST00000393400
  • ENSP00000377056
  • ENST00000450633
  • ENSP00000413428
  • ENST00000489960
  • ENSP00000418298
  • ENST00000648957
  • ENSP00000498161

Symbol
  • GPR175
  • TMEM227
  • GPR175
  • TPRA40
  • TMEM227
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
transcription factor
0.76
transcription factor perturbation
0.68
small molecule perturbation
0.63
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.84   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
SLC6A8
Tbio
Family:  Transporter
Novelty:  0.00332655
p_int:  0.999889349
p_ni:  0.000110651
Score:  0.171
Data Source:  BioPlex,STRINGDB
MFSD8
Tbio
Novelty:  0.03388459
p_int:  0.999212637
p_ni:  0.000774681
p_wrong:  0.000012682
Data Source:  BioPlex
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.998745246
p_ni:  0.001254747
p_wrong:  7e-9
Data Source:  BioPlex
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.99764734
p_ni:  0.002351815
p_wrong:  8.45e-7
Data Source:  BioPlex
BMPR1B
Tchem
Family:  Kinase
Novelty:  0.00698763
p_int:  0.995461649
p_ni:  0.000175482
p_wrong:  0.004362869
Score:  0.224
Data Source:  BioPlex,STRINGDB
TMEM143
Tdark
Novelty:  1.58941369
p_int:  0.99141606
p_ni:  0.008567507
p_wrong:  0.000016432
Score:  0.161
Data Source:  BioPlex,STRINGDB
SLC30A6
Tbio
Family:  Transporter
Novelty:  0.06083299
p_int:  0.984601134
p_ni:  0.013707169
p_wrong:  0.001691696
Data Source:  BioPlex
SNX13
Tbio
Novelty:  0.12227762
p_int:  0.983479558
p_ni:  0.001547945
p_wrong:  0.014972497
Score:  0.188
Data Source:  BioPlex,STRINGDB
TMEM63B
Tdark
Family:  IC
Novelty:  0.25017412
p_int:  0.970954055
p_ni:  0.029045937
p_wrong:  8e-9
Score:  0.153
Data Source:  BioPlex,STRINGDB
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
p_int:  0.966789374
p_ni:  0.025962657
p_wrong:  0.00724797
Score:  0.162
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
41
high density lipoprotein cholesterol measurement
2
1
2
38.8
triglyceride measurement
2
2
2
32.1
refractive error
1
1
1
17.7
BMI-adjusted waist-hip ratio
1
1
1
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
41
high density lipoprotein cholesterol measurement
2
38.8
triglyceride measurement
2
32.1
refractive error
1
17.7
BMI-adjusted waist-hip ratio
1
7.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein adipocyte associated 1
VGNC:7142
736579
Macaque
transmembrane protein adipocyte associated 1
707221
Mouse
MGI:1345190
24100
Rat
RGD:620858
85494
Dog
transmembrane protein adipocyte associated 1
VGNC:47752
484621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein adipocyte associated 1
Macaque
transmembrane protein adipocyte associated 1
Mouse
Rat
Dog
transmembrane protein adipocyte associated 1
Publication Statistics
PubMed Score 5.84
PubMed score by year
PubTator Score 2.39
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title