Tbio TPPP3 Tubulin polymerization-promoting protein family member 3

Protein Summary

Description

Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis.

Uniprot Accession IDs

• Q9BW30
• Q49AH9
• Q9Y326
• Q9Y6H0

Gene Name

• TPPP3

Ensembl ID

• ENST00000290942
• ENSP00000290942
• ENSG00000159713
• ENST00000393957
• ENSP00000377529
• ENST00000562206
• ENSP00000457275
• ENST00000564104
• ENSP00000462435

Symbol

• p20
• CGI-38
• TPPP/p20
• p25gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.61
PubMedID	0.55
disease perturbation	0.49
histone modification site profile	0.49
tissue	0.46

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Tubulin Polymerization-promoting Protein Family Member 3

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Tubulin Polymerization-promoting Protein Family Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.1   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.1   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0