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Tbio
TPM4
Tropomyosin alpha-4 chain

Protein Summary
Description
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity). Binds calcium (PubMed:1836432). This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300933
  • ENSP00000300933
  • ENSG00000167460
  • ENST00000344824
  • ENSP00000345230
  • ENST00000643579
  • ENSP00000495347
  • ENST00000646974
  • ENSP00000494125

Symbol
  • HEL-S-108
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.92
transcription factor binding site profile
0.76
microRNA
0.74
tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.02   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.02   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
TPM1
Tbio
Novelty:  0.00261206
p_int:  0.960545996
p_ni:  0.039454004
Score:  0.977
Data Source:  BioPlex,STRINGDB
ACTG2
Tbio
Novelty:  0.00304944
Score:  0.986
Data Source:  STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
Score:  0.985
Data Source:  STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
Score:  0.976
Data Source:  STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
Score:  0.974
Data Source:  STRINGDB
TPM2
Tbio
Novelty:  0.00406572
Score:  0.974
Data Source:  STRINGDB
TNNI2
Tbio
Novelty:  0.02772952
Score:  0.971
Data Source:  STRINGDB
TNNT3
Tbio
Novelty:  0.0212335
Score:  0.971
Data Source:  STRINGDB
TNNT1
Tbio
Novelty:  0.00072003
Score:  0.969
Data Source:  STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
Score:  0.968
Data Source:  STRINGDB
Pathways (8)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
8
11
99.6
platelet count
6
5
6
11.4
98.7
platelet crit
2
2
2
92.6
mean corpuscular hemoglobin concentration
2
2
2
91
red blood cell distribution width
2
2
2
78.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
11
99.6
platelet count
6
11.4
98.7
platelet crit
2
92.6
mean corpuscular hemoglobin concentration
2
91
red blood cell distribution width
2
78.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tropomyosin 4
719428
Mouse
MGI:2449202
326618
Rat
RGD:3899
24852
Pig
tropomyosin 4
397608
Opossum
tropomyosin 4
100617065
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tropomyosin 4
Mouse
Rat
Pig
tropomyosin 4
Opossum
tropomyosin 4
Publication Statistics
PubMed Score 170.02
PubMed score by year
PubTator Score 28.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title