TPI1
Triosephosphate isomerase
Protein Summary
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
- ENST00000229270
- ENSP00000229270
- ENSG00000111669
- ENST00000396705
- ENSP00000379933
- ENST00000488464
- ENSP00000475620
- ENST00000535434
- ENSP00000443599
- ENST00000613953
- ENSP00000484435
- TPI
- TIM
- TPI
- TPID
- HEL-S-49
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
protein complex | 0.98 | ||
virus perturbation | 0.94 | ||
interacting protein | 0.92 | ||
kinase perturbation | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1676.01 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 437 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1676.01 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 437 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0