You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TPD52L2
Tumor protein D54

Protein Summary
Description
This gene encodes a member of the tumor protein D52-like family. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. Expression of this gene may be a marker for breast cancer and acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217121
  • ENSP00000217121
  • ENSG00000101150
  • ENST00000346249
  • ENSP00000343547
  • ENST00000348257
  • ENSP00000343554
  • ENST00000351424
  • ENSP00000340006
  • ENST00000352482
  • ENSP00000344647
  • ENST00000358548
  • ENSP00000351350
  • ENST00000369927
  • ENSP00000358943

Symbol
  • D54
  • TPD54
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
kinase perturbation
0.95
transcription factor binding site profile
0.94
disease perturbation
0.93
virus perturbation
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.85   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.85   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
TPD52L1
Tbio
Novelty:  0.04828057
p_int:  0.999998828
p_ni:  0.000001062
p_wrong:  1.1e-7
Score:  0.422
Data Source:  BioPlex,STRINGDB
TPD52
Tbio
Novelty:  0.01337606
p_int:  0.999892937
p_ni:  0.000107063
Score:  0.703
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.999879466
p_ni:  0.000120534
Score:  0.207
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.999292736
p_ni:  0.000707264
Score:  0.185
Data Source:  BioPlex,STRINGDB
GABPB1
Tbio
Novelty:  0.01518726
p_int:  0.999123299
p_ni:  0.000876701
Score:  0.859
Data Source:  BioPlex,STRINGDB
GABPA
Tbio
Family:  TF
Novelty:  0.01731451
p_int:  0.981040037
p_ni:  0.018896876
p_wrong:  0.000063087
Score:  0.823
Data Source:  BioPlex,STRINGDB
MRPS2
Tbio
Novelty:  0.14756204
p_int:  0.928962457
p_ni:  0.071037543
Score:  0.54
Data Source:  BioPlex,STRINGDB
MAL2
Tbio
Novelty:  0.00874984
Score:  0.872
Data Source:  STRINGDB
ABHD5
Tbio
Family:  Enzyme
Novelty:  0.00806614
Score:  0.817
Data Source:  STRINGDB
SH3GLB1
Tbio
Novelty:  0.0314974
Score:  0.798
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
3
88
mean reticulocyte volume
1
1
1
79
alkaline phosphatase measurement
2
3
2
6.2
75.5
red blood cell density measurement
2
2
2
70.4
Agents acting on the renin-angiotensin system use measurement
1
1
1
68
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
88
mean reticulocyte volume
1
79
alkaline phosphatase measurement
2
6.2
75.5
red blood cell density measurement
2
70.4
Agents acting on the renin-angiotensin system use measurement
1
68
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor protein D52 like 2
458458
Mouse
MGI:1913564
66314
Rat
RGD:735167
296480
Dog
tumor protein D52 like 2
VGNC:47735
610715
Horse
tumor protein D52 like 2
100060965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor protein D52 like 2
Mouse
Rat
Dog
tumor protein D52 like 2
Horse
tumor protein D52 like 2
Publication Statistics
PubMed Score 27.85
PubMed score by year
PubTator Score 17.96
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title