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Tbio
TPD52L1
Tumor protein D53

Protein Summary
Description
This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368388
  • ENSP00000357373
  • ENSG00000111907
  • ENST00000368402
  • ENSP00000357387
  • ENST00000392482
  • ENSP00000376273
  • ENST00000524679
  • ENSP00000432787
  • ENST00000532429
  • ENSP00000435447
  • ENST00000534000
  • ENSP00000434142
  • ENST00000534199
  • ENSP00000432590

Symbol
  • D53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
PubMedID
0.84
transcription factor perturbation
0.8
small molecule perturbation
0.77
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.34   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.34   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0