Tbio TP53I3 Quinone oxidoreductase PIG3

Protein Summary

Description

May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q53FA7
• D6W533
• O14679
• O14685
• Q38G78
• Q6JLE7
• Q9BWB8

Gene Name

• TP53I3

Ensembl ID

• ENST00000238721
• ENSP00000238721
• ENSG00000115129
• ENST00000335934
• ENSP00000337834
• ENST00000407482
• ENSP00000384414

Symbol

• PIG3
• PIG3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.88
protein domain	0.85
cell type or tissue	0.73
kinase perturbation	0.71
PubMedID	0.71

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Quinone Oxidoreductase Pig3

Protein / Oxidoreductase / Dehydrogenase / Quinone Oxidoreductase Pig3

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Quinone Oxidoreductase Pig3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.24   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 360   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.24   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0