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Tbio
TP53BP2
Apoptosis-stimulating of p53 protein 2

Protein Summary
Description
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42. This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343537
  • ENSP00000341957
  • ENSG00000143514
  • ENST00000391878
  • ENSP00000375750

Symbol
  • ASPP2
  • BBP
  • BBP
  • 53BP2
  • ASPP2
  • P53BP2
  • PPP1R13A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
virus perturbation
0.9
histone modification site profile
0.8
transcription factor binding site profile
0.78
hub protein
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.17   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.17   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
RASSF8
Tbio
Novelty:  0.09245647
p_int:  0.999999894
p_ni:  9.2e-8
p_wrong:  1.3e-8
Score:  0.921
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999243
p_ni:  7.57e-7
p_wrong:  1e-9
Score:  0.915
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999998938
p_ni:  0.000001056
p_wrong:  6e-9
Score:  0.932
Data Source:  BioPlex,STRINGDB
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.999996926
p_ni:  0.000002853
p_wrong:  2.21e-7
Score:  0.762
Data Source:  BioPlex,STRINGDB
FRMD6
Tbio
Novelty:  0.0034642
p_int:  0.999902327
p_ni:  0.000097673
Score:  0.864
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999847062
p_ni:  0.000150303
p_wrong:  0.000002635
Data Source:  BioPlex
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999143857
p_ni:  0.000856143
Data Source:  BioPlex
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.998560089
p_ni:  0.001439823
p_wrong:  8.8e-8
Data Source:  BioPlex
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.982032244
p_ni:  0.017967728
p_wrong:  2.9e-8
Data Source:  BioPlex
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.954076205
p_ni:  0.045920565
p_wrong:  0.00000323
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Activation of BH3-only proteins (R-HSA-114452)

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Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of PUMA and translocation to mitochondria
Apoptosis
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
AgBase
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
67.7
waist-hip ratio
1
1
1
31.4
alpha-carotene measurement
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
67.7
waist-hip ratio
1
31.4
alpha-carotene measurement
1
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor protein p53 binding protein 2
VGNC:1696
457766
Macaque
tumor protein p53 binding protein 2
705383
Mouse
MGI:2138319
209456
Rat
RGD:1305461
305025
Dog
tumor protein p53 binding protein 2
VGNC:47721
490397
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor protein p53 binding protein 2
Macaque
tumor protein p53 binding protein 2
Mouse
Rat
Dog
tumor protein p53 binding protein 2
Publication Statistics
PubMed Score 107.17
PubMed score by year
PubTator Score 73.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title