Tchem TP53 Cellular tumor antigen p53

Protein Summary

Description

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492). This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• P04637
• Q15086
• Q15087
• Q15088
• Q16535
• Q16807
• Q16808
• Q16809
• Q16810
• Q16811
• Q16848
• Q2XN98
• Q3LRW1
• Q3LRW2
• Q3LRW3
• Q3LRW4
• Q3LRW5
• Q86UG1
• Q8J016
• Q99659
• Q9BTM4
• Q9HAQ8
• Q9NP68
• Q9NPJ2
• Q9NZD0
• Q9UBI2
• Q9UQ61

Gene Name

• TP53

Ensembl ID

• ENST00000269305
• ENSP00000269305
• ENSG00000141510
• ENST00000420246
• ENSP00000391127
• ENST00000445888
• ENSP00000391478
• ENST00000455263
• ENSP00000398846
• ENST00000504290
• ENSP00000484409
• ENST00000504937
• ENSP00000481179
• ENST00000510385
• ENSP00000478499
• ENST00000610292
• ENSP00000478219
• ENST00000610538
• ENSP00000480868
• ENST00000617185
• ENSP00000482258
• ENST00000619485
• ENSP00000482537
• ENST00000620739
• ENSP00000481638
• ENST00000622645
• ENSP00000482222

Symbol

• P53
• P53
• BCC7
• LFS1
• BMFS5
• TRP53

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
chemical	1
hub protein	1
interacting protein	1

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Cellular Tumor Antigen P53

Protein / ... / P53-like Transcription Factor / Cellular Tumor Antigen P53

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / P53-like Transcription Factor / Cellular Tumor Antigen P53

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59503.16   (req: < 5)

Gene RIFs: 9473   (req: <= 3)

Antibodies: 8417   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59503.16   (req: >= 5)

Gene RIFs: 9473   (req: > 3)

Antibodies: 8417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 110

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0