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Tbio
TOR1AIP1
Torsin-1A-interacting protein 1

Protein Summary
Description
Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528443
  • ENSP00000435365
  • ENSG00000143337
  • ENST00000606911
  • ENSP00000476687

Symbol
  • LAP1
  • LAP1
  • LAP1B
  • LGMD2Y
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
transcription factor binding site profile
0.91
kinase perturbation
0.88
disease perturbation
0.87
transcription factor perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.73   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.73   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.999166029
p_ni:  0.000833971
Score:  0.163
Data Source:  BioPlex,STRINGDB
MAD2L1BP
Tbio
Novelty:  0.48374717
p_int:  0.991658253
p_ni:  0.005853373
p_wrong:  0.002488374
Score:  0.511
Data Source:  BioPlex,STRINGDB
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.991613596
p_ni:  0.008386405
Score:  0.177
Data Source:  BioPlex,STRINGDB
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.839626894
p_ni:  0.160373107
Data Source:  BioPlex
CA10
Tbio
Family:  Enzyme
Novelty:  0.01053152
p_int:  0.839370635
p_ni:  0.160629365
Score:  0.207
Data Source:  BioPlex,STRINGDB
AIFM1
Tbio
Novelty:  0.00940088
p_int:  0.801454933
p_ni:  0.198545067
Score:  0.187
Data Source:  BioPlex,STRINGDB
TOR1A
Tbio
Novelty:  0.00056274
Score:  0.858
Data Source:  STRINGDB
RIF1
Tbio
Novelty:  0.34360368
Score:  0.819
Data Source:  STRINGDB
TOR3A
Tbio
Novelty:  0.11588309
Score:  0.713
Data Source:  STRINGDB
CCDC120
Tbio
Novelty:  0.48574876
Score:  0.687
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
67.3
mean corpuscular volume
1
2
2
64.5
smoking status measurement
2
1
2
61
monocyte percentage of leukocytes
1
1
1
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
67.3
mean corpuscular volume
2
64.5
smoking status measurement
2
61
monocyte percentage of leukocytes
1
29.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
torsin 1A interacting protein 1
VGNC:1695
741030
Macaque
torsin 1A interacting protein 1
716611
Mouse
MGI:3582693
208263
Rat
RGD:628851
246314
Dog
torsin 1A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29456]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
torsin 1A interacting protein 1
Macaque
torsin 1A interacting protein 1
Mouse
Rat
Dog
torsin 1A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29456]
Publication Statistics
PubMed Score 19.73
PubMed score by year
PubTator Score 47.08
PubTator score by year
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Related Publications
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PMID
Year
Title