You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TOP3A
DNA topoisomerase 3-alpha

Protein Summary
Description
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. As an essential component of the RMI complex it is involved in chromosome separation and the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Has DNA decatenation activity (PubMed:30057030). It is required for mtDNA decatenatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321105
  • ENSP00000321636
  • ENSG00000177302
  • ENST00000542570
  • ENSP00000442336
  • ENST00000580095
  • ENSP00000462790
  • ENST00000638894
  • ENSP00000492229
  • ENSG00000284238
  • ENST00000639065
  • ENSP00000491260
  • ENST00000640743
  • ENSP00000491689

Symbol
  • TOP3
  • TOP3
  • PEOB5
  • ZGRF7
  • MGRISCE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.89
tissue
0.72
cellular component
0.7
histone modification site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.49   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 250.49   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0