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Tbio
TOMM7
Mitochondrial import receptor subunit TOM7 homolog

Protein Summary
Description
Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria. This gene encodes a subunit of the translocase of the outer mitochondrial membrane. The encoded protein regulates the assembly and stability of the translocase complex. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358435
  • ENSP00000351214
  • ENSG00000196683

Symbol
  • TOM7
  • TOMM07
  • TOM7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
disease perturbation
0.87
small molecule perturbation
0.84
transcription factor binding site profile
0.81
virus perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 11   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
AMY2A
Tclin
Family:  Enzyme
Novelty:  0.00132709
p_int:  0.998978246
p_ni:  0.001021753
p_wrong:  1e-9
Data Source:  BioPlex
TOMM40L
Tdark
Novelty:  0.24691216
p_int:  0.900772415
p_ni:  4.81e-7
p_wrong:  0.099227104
Score:  0.82
Data Source:  BioPlex,STRINGDB
TOMM40
Tbio
Novelty:  0.0041507
p_int:  0.833912544
p_ni:  0.166087455
Score:  0.998
Data Source:  BioPlex,STRINGDB
TOMM22
Tbio
Novelty:  0.01217913
Score:  0.999
Data Source:  STRINGDB
TOMM70
Tbio
Novelty:  0.00943973
Score:  0.998
Data Source:  STRINGDB
TOMM20
Tbio
Novelty:  0.00275824
Score:  0.99
Data Source:  STRINGDB
TOMM5
Tdark
Novelty:  0.07962801
Score:  0.987
Data Source:  STRINGDB
TOMM6
Tbio
Novelty:  0.1033676
Score:  0.986
Data Source:  STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
Score:  0.966
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.952
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Mitochondrial protein import
Reactome
Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Mitochondrial protein import
Mitophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
4
6
93.3
eosinophil count
3
2
3
85.7
pulse pressure measurement
1
1
1
77.1
serum non-albumin protein measurement
1
2
2
74.1
myeloid white cell count
1
1
1
73.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
6
93.3
eosinophil count
3
85.7
pulse pressure measurement
1
77.1
serum non-albumin protein measurement
2
74.1
myeloid white cell count
1
73.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of outer mitochondrial membrane 7
VGNC:14100
107966413
Mouse
MGI:1913419
66169
Rat
RGD:1591393
685620
Horse
translocase of outer mitochondrial membrane 7
100630688
Pig
translocase of outer mitochondrial membrane 7
100037982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of outer mitochondrial membrane 7
Mouse
Rat
Horse
translocase of outer mitochondrial membrane 7
Pig
translocase of outer mitochondrial membrane 7
Publication Statistics
PubMed Score 24.69
PubMed score by year
PubTator Score 5.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title