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Tdark
TOMM40L
Mitochondrial import receptor subunit TOM40B

Protein Summary
Description
Potential channel-forming protein implicated in import of protein precursors into mitochondria.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367987
  • ENSP00000356966
  • ENSG00000158882
  • ENST00000367988
  • ENSP00000356967
  • ENST00000545897
  • ENSP00000443233

Symbol
  • TOMM40B
  • TOMM40B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor binding site profile
0.85
kinase perturbation
0.66
transcription factor
0.66
microRNA
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
TOMM22
Tbio
Novelty:  0.01217913
p_int:  0.999646298
p_wrong:  0.000353702
Score:  0.921
Data Source:  BioPlex,STRINGDB
TOMM7
Tbio
Novelty:  0.03885154
p_int:  0.900772415
p_ni:  4.81e-7
p_wrong:  0.099227104
Score:  0.82
Data Source:  BioPlex,STRINGDB
TOMM70
Tbio
Novelty:  0.00943973
Score:  0.865
Data Source:  STRINGDB
TOMM20
Tbio
Novelty:  0.00275824
Score:  0.851
Data Source:  STRINGDB
SAMM50
Tbio
Novelty:  0.00553631
Score:  0.849
Data Source:  STRINGDB
TOMM20L
Tdark
Novelty:  4.50556416
Score:  0.844
Data Source:  STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.833
Data Source:  STRINGDB
TOMM40
Tbio
Novelty:  0.0041507
Score:  0.807
Data Source:  STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
Score:  0.801
Data Source:  STRINGDB
VDAC3
Tbio
Novelty:  0.0095068
Score:  0.785
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
5
5
94.7
serum non-albumin protein measurement
1
4
4
93.7
mean platelet volume
3
2
4
93
blood metabolite measurement
2
2
2
83
4
2
0
1.1
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
5
94.7
serum non-albumin protein measurement
4
93.7
mean platelet volume
4
93
blood metabolite measurement
2
83
0
1.1
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of outer mitochondrial membrane 40 like
VGNC:8555
469846
Macaque
translocase of outer mitochondrial membrane 40 like
100426891
Mouse
MGI:3589112
641376
Rat
RGD:1562006
304971
Dog
translocase of outer mitochondrial membrane 40 like
VGNC:49629
609819
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of outer mitochondrial membrane 40 like
Macaque
translocase of outer mitochondrial membrane 40 like
Mouse
Rat
Dog
translocase of outer mitochondrial membrane 40 like
Publication Statistics
PubMed Score 2.85
PubMed score by year
PubTator Score 1.78
PubTator score by year
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Related Publications
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PMID
Year
Title