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Tbio
TOMM40
Mitochondrial import receptor subunit TOM40 homolog

Protein Summary
Description
Channel-forming protein essential for import of protein precursors into mitochondria. The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252487
  • ENSP00000252487
  • ENSG00000130204
  • ENST00000405636
  • ENSP00000385184
  • ENST00000426677
  • ENSP00000410339
  • ENST00000592434
  • ENSP00000466084

Symbol
  • C19orf1
  • PEREC1
  • TOM40
  • TOM40
  • PEREC1
  • C19orf1
  • PER-EC1
  • D19S1177E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
disease perturbation
0.93
histone modification site profile
0.89
phenotype
0.89
transcription factor binding site profile
0.89


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.71   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.71   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (240)
TOMM22
Tbio
Novelty:  0.01217913
p_int:  0.999943778
p_ni:  0.000056222
Score:  0.997
Data Source:  BioPlex,STRINGDB
NCR3LG1
Tbio
Novelty:  0.02681936
p_int:  0.969362369
p_ni:  0.030637631
Score:  0.185
Data Source:  BioPlex,STRINGDB
WNT4
Tbio
Novelty:  0.00276803
p_int:  0.909849471
p_ni:  0.090150529
Score:  0.189
Data Source:  BioPlex,STRINGDB
KRBA1
Tdark
Novelty:  2.59384945
p_int:  0.890735583
p_ni:  0.109264417
Score:  0.173
Data Source:  BioPlex,STRINGDB
KLRF1
Tbio
Novelty:  0.05732414
p_int:  0.879009511
p_ni:  0.120990487
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
NDUFB8
Tclin
Family:  Enzyme
Novelty:  0.019021
p_int:  0.877480942
p_ni:  0.122519058
Score:  0.945
Data Source:  BioPlex,STRINGDB
FOXRED2
Tdark
Family:  Enzyme
Novelty:  0.33139597
p_int:  0.871906864
p_ni:  0.128093136
Score:  0.236
Data Source:  BioPlex,STRINGDB
CYP2C9
Tchem
Novelty:  0.00041914
p_int:  0.869746857
p_ni:  0.130253143
Score:  0.335
Data Source:  BioPlex,STRINGDB
TOMM7
Tbio
Novelty:  0.03885154
p_int:  0.833912544
p_ni:  0.166087455
Score:  0.998
Data Source:  BioPlex,STRINGDB
TOMM70
Tbio
Novelty:  0.00943973
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Mitochondrial protein import
Reactome
Mitophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Mitochondrial protein import
Mitophagy
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (119)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
35
76
115
8
100
apolipoprotein B measurement
2
65
66
100
total cholesterol measurement
21
63
93
6.8
100
C-reactive protein measurement
14
60
76
21.8
100
27
64
2
2.7
99.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
115
8
100
apolipoprotein B measurement
66
100
total cholesterol measurement
93
6.8
100
C-reactive protein measurement
76
21.8
100
2
2.7
99.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
translocase of outer mitochondrial membrane 40
713297
Mouse
MGI:1858259
53333
Rat
RGD:1303022
308416
Dog
translocase of outer mitochondrial membrane 40
VGNC:49033
611055
Horse
translocase of outer mitochondrial membrane 40
VGNC:50512
100146715
Species
Name
OMA
EggNOG
Inparanoid
Macaque
translocase of outer mitochondrial membrane 40
Mouse
Rat
Dog
translocase of outer mitochondrial membrane 40
Horse
translocase of outer mitochondrial membrane 40
Publication Statistics
PubMed Score 243.71
PubMed score by year
PubTator Score 150.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title