Protein Summary
Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Apr 2017]
- ENST00000318094
- ENSP00000312860
- ENSG00000175662
- ENST00000379504
- ENSP00000368818
- ENST00000395739
- ENSP00000379088
- ENST00000478943
- ENSP00000463313
- ENST00000535933
- ENSP00000438621
- ENST00000581396
- ENSP00000464297
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
transcription factor perturbation | 0.84 | ||
histone modification site profile | 0.78 | ||
transcription factor | 0.78 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.29 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 143 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.29 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 143 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (51)
SZRD1
Novelty: 0.81300551
p_int: 0.997565177
p_ni: 0.002422673
p_wrong: 0.000012151
Score: 0.485
Data Source: BioPlex,STRINGDB
NDUFA6
Family: Enzyme
Novelty: 0.01236094
p_int: 0.99686957
p_ni: 0.00313043
Score: 0.622
Data Source: BioPlex,STRINGDB
TOLLIP
Novelty: 0.01032371
p_int: 0.988422665
p_ni: 0.011577335
Score: 0.708
Data Source: BioPlex,STRINGDB
CUEDC1
Novelty: 0.14401061
p_int: 0.980503363
p_ni: 0.019496638
Score: 0.665
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: netpath | EGFR1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
EGFR1 | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 2 | 4 | 93.9 | |||||
waist-hip ratio | 2 | 7 | 7 | 89 | |||||
BMI-adjusted waist-hip ratio | 2 | 7 | 7 | 88 | |||||
lymphocyte count | 2 | 2 | 2 | 86.8 | |||||
4 | 3 | 3 | 1.1 | 77.8 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 4 | 93.9 | |||||
waist-hip ratio | 7 | 89 | |||||
BMI-adjusted waist-hip ratio | 7 | 88 | |||||
lymphocyte count | 2 | 86.8 | |||||
3 | 1.1 | 77.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | target of myb1 like 2 membrane trafficking protein | VGNC:9731 | 454481 | |||||
Macaque | target of myb1 like 2 membrane trafficking protein | 699471 | ||||||
Mouse | MGI:2443306 | 216810 | ||||||
Dog | target of myb1 like 2 membrane trafficking protein | VGNC:47709 | 489540 | |||||
Horse | target of myb1 like 2 membrane trafficking protein | VGNC:24409 | 100052159 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | target of myb1 like 2 membrane trafficking protein | |||||
Macaque | target of myb1 like 2 membrane trafficking protein | |||||
Mouse | ||||||
Dog | target of myb1 like 2 membrane trafficking protein | |||||
Horse | target of myb1 like 2 membrane trafficking protein | |||||
Publication Statistics
PubMed Score 4.29
PubMed score by year
PubTator Score 4.66
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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