Tbio TNXB Tenascin-X

Protein Summary

Description

Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P22105
• P78530
• P78531
• Q08424
• Q08AM0
• Q08AM1
• Q59GU7
• Q5SQD3
• Q5ST74
• Q7L8Q4
• Q8N4R1
• Q9NPK9
• Q9UC10
• Q9UC11
• Q9UC12
• Q9UC13
• Q9UMG7
• TN-X

Gene Name

• TNXB

Ensembl ID

• ENST00000375244
• ENSP00000364393
• ENSG00000168477
• ENST00000451343
• ENSP00000407685
• ENST00000546684
• ENSP00000447694
• ENSG00000236236
• ENST00000550539
• ENSP00000448326
• ENSG00000229353
• ENST00000644971
• ENSP00000496448

Symbol

• HXBL
• TNX
• TNXB1
• TNXB2
• XB
• XB
• TNX
• XBS
• EDS3
• HXBL
• TENX
• TN-X
• VUR8
• TNXB1
• TNXB2
• TNXBS
• EDSCLL
• EDSCLL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	1
protein domain	0.97
phenotype	0.79
disease	0.75
PubMedID	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.88   (req: < 5)

Gene RIFs: 48   (req: <= 3)

Antibodies: 201   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.88   (req: >= 5)

Gene RIFs: 48   (req: > 3)

Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0