Protein Summary
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.
- ENST00000254051
- ENSP00000254051
- ENSG00000131746
- CTEN
- CTEN
- PP14434
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.76 | ||
gene perturbation | 0.65 | ||
cell type or tissue | 0.63 | ||
PubMedID | 0.61 | ||
microRNA | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.61 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 188 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.61 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 188 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (57)
PPP3CC
Family: Enzyme
Novelty: 0.02633046
p_int: 0.999997259
p_ni: 0.000002741
p_wrong: 1e-9
Data Source: BioPlex
PPP3R1
Novelty: 0.00263264
p_int: 0.999911139
p_ni: 0.000088861
Score: 0.159
Data Source: BioPlex,STRINGDB
PPP3CB
Family: Enzyme
Novelty: 0.02156713
p_int: 0.999666361
p_ni: 0.00033364
Data Source: BioPlex
QPRT
Family: Enzyme
Novelty: 0.00781554
p_int: 0.998699114
p_ni: 0.000240922
p_wrong: 0.001059963
Data Source: BioPlex
PPP3CA
Family: Enzyme
Novelty: 0.00234189
p_int: 0.920636182
p_ni: 0.079363818
Score: 0.2
Data Source: BioPlex,STRINGDB
THNSL1
Family: Enzyme
Novelty: 1.98275016
p_int: 0.874198573
p_ni: 0.117275993
p_wrong: 0.008525433
Data Source: BioPlex
ACACA
Family: Enzyme
Novelty: 0.00248313
p_int: 0.861707664
p_ni: 0.138292336
Data Source: BioPlex
ABRAXAS2
Novelty: 0.20430604
p_int: 0.800615367
p_ni: 0.19938462
p_wrong: 1.3e-8
Data Source: BioPlex
Nearest Tclin Targets
Pathways (7)
Reactome (5)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | MET interacts with TNS proteins | ||||
Reactome | MET promotes cell motility | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by MET | ||||
Reactome | Signaling by Receptor Tyrosine Kinases | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
MET interacts with TNS proteins | ||||
MET promotes cell motility | ||||
Signal Transduction | ||||
Signaling by MET | ||||
Signaling by Receptor Tyrosine Kinases | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 1 | 2 | 75.5 | |||||
neutrophil percentage of leukocytes | 1 | 2 | 2 | 72.4 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 70.9 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 35 | |||||
body height | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 75.5 | |||||
neutrophil percentage of leukocytes | 2 | 72.4 | |||||
lymphocyte percentage of leukocytes | 1 | 70.9 | |||||
BMI-adjusted hip circumference | 1 | 35 | |||||
body height | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tensin 4 | VGNC:10050 | 454653 | |||||
Macaque | tensin 4 | 701075 | ||||||
Mouse | MGI:2144377 | 217169 | ||||||
Rat | RGD:1310402 | 303517 | ||||||
Dog | tensin 4 | VGNC:47703 | 491012 | |||||
Publication Statistics
PubMed Score 23.61
PubMed score by year
PubTator Score 29.23
PubTator score by year
Related Publications
Text Mined References (36)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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