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Tbio
TNS4
Tensin-4

Protein Summary
Description
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254051
  • ENSP00000254051
  • ENSG00000131746

Symbol
  • CTEN
  • CTEN
  • PP14434
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
gene perturbation
0.65
cell type or tissue
0.63
PubMedID
0.61
microRNA
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.61   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.61   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
PPP3CC
Tbio
Family:  Enzyme
Novelty:  0.02633046
p_int:  0.999997259
p_ni:  0.000002741
p_wrong:  1e-9
Data Source:  BioPlex
PPP3R1
Tbio
Novelty:  0.00263264
p_int:  0.999911139
p_ni:  0.000088861
Score:  0.159
Data Source:  BioPlex,STRINGDB
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
p_int:  0.999666361
p_ni:  0.00033364
Data Source:  BioPlex
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
p_int:  0.998699114
p_ni:  0.000240922
p_wrong:  0.001059963
Data Source:  BioPlex
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  0.920636182
p_ni:  0.079363818
Score:  0.2
Data Source:  BioPlex,STRINGDB
THNSL1
Tdark
Family:  Enzyme
Novelty:  1.98275016
p_int:  0.874198573
p_ni:  0.117275993
p_wrong:  0.008525433
Data Source:  BioPlex
ACACA
Tchem
Family:  Enzyme
Novelty:  0.00248313
p_int:  0.861707664
p_ni:  0.138292336
Data Source:  BioPlex
ABRAXAS2
Tbio
Novelty:  0.20430604
p_int:  0.800615367
p_ni:  0.19938462
p_wrong:  1.3e-8
Data Source:  BioPlex
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.94
Data Source:  Reactome,STRINGDB
MET
Tclin
Family:  Kinase
Novelty:  0.00037995
Score:  0.923
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
MET interacts with TNS proteins (R-HSA-8875513)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET interacts with TNS proteins
Reactome
MET promotes cell motility
Reactome
Signal Transduction
Reactome
Signaling by MET
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
MET interacts with TNS proteins
MET promotes cell motility
Signal Transduction
Signaling by MET
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
75.5
neutrophil percentage of leukocytes
1
2
2
72.4
lymphocyte percentage of leukocytes
1
1
1
70.9
BMI-adjusted hip circumference
1
1
1
35
body height
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
75.5
neutrophil percentage of leukocytes
2
72.4
lymphocyte percentage of leukocytes
1
70.9
BMI-adjusted hip circumference
1
35
body height
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tensin 4
VGNC:10050
454653
Macaque
tensin 4
701075
Mouse
MGI:2144377
217169
Rat
RGD:1310402
303517
Dog
tensin 4
VGNC:47703
491012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tensin 4
Macaque
tensin 4
Mouse
Rat
Dog
tensin 4
Publication Statistics
PubMed Score 23.61
PubMed score by year
PubTator Score 29.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title