Tbio TNS3 Tensin-3

Protein Summary

Description

May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).

Uniprot Accession IDs

• Q68CZ2
• B2RNV1
• Q6IPQ2
• Q8IZW7
• Q8NAD0
• Q96PE0
• Q96S48

Gene Name

• TNS3

Ensembl ID

• ENST00000311160
• ENSP00000312143
• ENSG00000136205
• ENST00000442536
• ENSP00000389285
• ENST00000458317
• ENSP00000388318

Symbol

• TEM6
• TENS1
• TPP
• TEM6
• TENS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
protein domain	0.97
virus perturbation	0.9
PubMedID	0.86
cell type or tissue	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.35   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.35   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0