You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNRC6B
Trinucleotide repeat-containing gene 6B protein

Protein Summary
Description
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301923
  • ENSP00000306759
  • ENSG00000100354
  • ENST00000335727
  • ENSP00000338371
  • ENST00000402203
  • ENSP00000384795
  • ENST00000454349
  • ENSP00000401946

Symbol
  • KIAA1093
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
pathway
0.99
virus perturbation
0.98
interacting protein
0.97
transcription factor perturbation
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.31   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.31   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
AGO2
Tbio
Novelty:  0.00057003
Score:  0.99
Data Source:  Reactome,STRINGDB
MOV10
Tbio
Family:  Enzyme
Novelty:  0.01963275
Score:  0.99
Data Source:  Reactome,STRINGDB
AGO3
Tbio
Novelty:  0.01664154
Score:  0.989
Data Source:  Reactome,STRINGDB
AGO1
Tbio
Novelty:  0.00157424
Score:  0.988
Data Source:  Reactome,STRINGDB
AGO4
Tbio
Novelty:  0.00468833
Score:  0.967
Data Source:  Reactome,STRINGDB
KMT2E
Tbio
Family:  Epigenetic
Novelty:  0.01893047
Score:  0.928
Data Source:  STRINGDB
PHC1
Tbio
Novelty:  0.01530622
Score:  0.925
Data Source:  STRINGDB
TNRC6C
Tbio
Novelty:  0.09764186
Score:  0.923
Data Source:  STRINGDB
PTEN
Tchem
Family:  Enzyme
Novelty:  0.00013818
Score:  0.921
Data Source:  STRINGDB
TNRC6A
Tbio
Novelty:  0.00505282
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
4
6
88.7
chronotype measurement
2
4
2
1
88.3
mean corpuscular hemoglobin concentration
1
1
1
79.5
5
7
0
1.1
78.1
reticulocyte measurement
2
2
2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
88.7
chronotype measurement
2
1
88.3
mean corpuscular hemoglobin concentration
1
79.5
0
1.1
78.1
reticulocyte measurement
2
76.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
trinucleotide repeat containing 6B
704630
Mouse
MGI:2443730
213988
Rat
RGD:621428
192178
Horse
trinucleotide repeat containing 6B
VGNC:24399
100070414
Cow
trinucleotide repeat containing 6B
VGNC:36205
528167
Species
Name
OMA
EggNOG
Inparanoid
Macaque
trinucleotide repeat containing 6B
Mouse
Rat
Horse
trinucleotide repeat containing 6B
Cow
trinucleotide repeat containing 6B
Publication Statistics
PubMed Score 21.31
PubMed score by year
PubTator Score 12.31
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title