Protein Summary
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adh ...more
- ENST00000263525
- ENSP00000263525
- ENSG00000116147
- ENST00000367674
- ENSP00000356646
- TN-R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
biological process | 0.82 | ||
disease | 0.69 | ||
gene perturbation | 0.67 | ||
cell type or tissue | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.74 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 114 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.74 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 114 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (44)
Nearest Tclin Targets
Pathways (16)
Reactome (2)
KEGG (5)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ECM proteoglycans | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ECM proteoglycans | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Components (6)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
biological sex | 1 | 1 | 1 | 53.3 | |||||
1 | 1 | 0 | 1.5 | 21.5 | |||||
disease progression measurement | 1 | 1 | 0 | 1.5 | 21.5 | ||||
testosterone measurement | 1 | 1 | 1 | 17.8 | |||||
intelligence | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
biological sex | 1 | 53.3 | |||||
0 | 1.5 | 21.5 | |||||
disease progression measurement | 0 | 1.5 | 21.5 | ||||
testosterone measurement | 1 | 17.8 | |||||
intelligence | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | tenascin R | VGNC:1694 | 469594 | |||||
Macaque | tenascin R | 708707 | ||||||
Mouse | MGI:99516 | 21960 | ||||||
Rat | RGD:3886 | 25567 | ||||||
Dog | tenascin R | VGNC:47697 | 490334 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | tenascin R | |||||
Macaque | tenascin R | |||||
Mouse | ||||||
Rat | ||||||
Dog | tenascin R | |||||
Publication Statistics
PubMed Score 22.74
PubMed score by year
PubTator Score 129.65
PubTator score by year
Related Publications
Text Mined References (46)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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