Protein Summary
Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010]
- ENST00000265388
- ENSP00000265388
- ENSG00000064419
- ENST00000471234
- ENSP00000418646
- IPO12
- IPO12
- TRNSR
- LGMD1F
- LGMDD2
- MTR10A
- TRN-SR
- TRN-SR2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
transcription factor binding site profile | 0.9 | ||
trait | 0.86 | ||
kinase perturbation | 0.84 | ||
microRNA | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.51 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 137 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.51 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 137 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (159)
RSRP1
Novelty: 0.74980508
p_int: 0.999878115
p_ni: 0.000121885
Score: 0.177
Data Source: BioPlex,STRINGDB
STX5
Novelty: 0.00964918
p_int: 0.999310181
p_ni: 0.000689819
Score: 0.234
Data Source: BioPlex,STRINGDB
VIPR2
Family: GPCR
Novelty: 0.00463802
p_int: 0.996548119
p_ni: 0.003451881
Data Source: BioPlex
P2RY12
Family: GPCR
Novelty: 0.00035406
p_int: 0.980733954
p_ni: 0.019266046
Data Source: BioPlex
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (4)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (19)
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
17 | 14 | 0 | 1.6 | 99.5 | |||||
6 | 7 | 2 | 1.2 | 96.9 | |||||
8 | 7 | 0 | 1.5 | 96.9 | |||||
1 | 2 | 0 | 1.3 | 91.7 | |||||
2 | 3 | 0 | 1.5 | 85.1 | |||||
Items per page:
1 – 5 of 19
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.6 | 99.5 | |||||
2 | 1.2 | 96.9 | |||||
0 | 1.5 | 96.9 | |||||
0 | 1.3 | 91.7 | |||||
0 | 1.5 | 85.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transportin 3 | VGNC:4545 | 463715 | |||||
Macaque | transportin 3 | 700852 | ||||||
Mouse | MGI:1196412 | 320938 | ||||||
Rat | RGD:1308938 | 296954 | ||||||
Dog | transportin 3 | VGNC:47696 | 482263 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transportin 3 | |||||
Macaque | transportin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transportin 3 | |||||
Publication Statistics
PubMed Score 64.51
PubMed score by year
PubTator Score 38.43
PubTator score by year
Related Publications
Text Mined References (61)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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