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Tbio
TNPO2
Transportin-2

Protein Summary
Description
Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356861
  • ENSP00000349321
  • ENSG00000105576
  • ENST00000425528
  • ENSP00000407182
  • ENST00000450764
  • ENSP00000397379
  • ENST00000588216
  • ENSP00000465625
  • ENST00000592287
  • ENSP00000468434

Symbol
  • IPO3
  • TRN2
  • KPNB2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
interacting protein
0.93
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
transcription factor
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.24   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.24   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
SIGLECL1
Tdark
p_int:  0.999991118
p_ni:  0.000008882
Data Source:  BioPlex
VSIG2
Tbio
Novelty:  0.32398032
p_int:  0.999651351
p_ni:  0.000348649
Data Source:  BioPlex
TMA16
Tdark
Novelty:  0.89810617
p_int:  0.999425248
p_ni:  0.000574752
Data Source:  BioPlex
TRARG1
Tbio
Novelty:  0.07729433
p_int:  0.998101407
p_ni:  0.001898592
p_wrong:  1e-9
Data Source:  BioPlex
RP2
Tbio
Novelty:  0.12345247
p_int:  0.986261152
p_ni:  0.013738848
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.982660425
p_ni:  0.017339575
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.981866905
p_ni:  0.018133095
Data Source:  BioPlex
CD274
Tclin
Novelty:  0.00013449
p_int:  0.979700909
p_ni:  0.020295602
p_wrong:  0.000003489
Data Source:  BioPlex
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.975921747
p_ni:  0.024078241
p_wrong:  1.2e-8
Data Source:  BioPlex
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.969361287
p_ni:  0.030638712
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
83.7
mean corpuscular volume
1
1
1
66.6
blood protein measurement
1
1
1
50
educational attainment
1
2
2
49.9
cathepsin L1 measurement
1
1
1
32.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
83.7
mean corpuscular volume
1
66.6
blood protein measurement
1
50
educational attainment
2
49.9
cathepsin L1 measurement
1
32.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transportin 2
VGNC:2217
455748
Macaque
transportin 2
717710
Mouse
MGI:2384849
212999
Rat
RGD:1310356
304670
Dog
transportin 2
VGNC:47695
484930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transportin 2
Macaque
transportin 2
Mouse
Rat
Dog
transportin 2
Publication Statistics
PubMed Score 9.24
PubMed score by year
PubTator Score 9.61
PubTator score by year
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Related Publications
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PMID
Year
Title