Protein Summary
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears a ...more
- ENST00000337273
- ENSP00000336712
- ENSG00000083312
- ENST00000506351
- ENSP00000425118
- ENST00000523768
- ENSP00000428899
- KPNB2
- MIP1
- TRN
- MIP
- TRN
- IPO2
- MIP1
- KPNB2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
disease perturbation | 0.99 | ||
viral protein | 0.98 | ||
virus perturbation | 0.94 | ||
microRNA | 0.89 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.14 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 266 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 64.14 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 266 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (240)
VSIG2
Novelty: 0.32398032
p_int: 0.939726595
p_ni: 0.060273405
Score: 0.19
Data Source: BioPlex,STRINGDB
TMA16
Novelty: 0.89810617
p_int: 0.894770571
p_ni: 0.105229429
Score: 0.188
Data Source: BioPlex,STRINGDB
TRARG1
Novelty: 0.07729433
p_int: 0.846854256
p_ni: 0.153145744
Score: 0.309
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cilium Assembly | ||||
Reactome | Intraflagellar transport | ||||
Reactome | Metabolism of RNA | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | Regulation of mRNA stability by proteins that bind AU-rich elements | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cilium Assembly | ||||
Intraflagellar transport | ||||
Metabolism of RNA | ||||
Organelle biogenesis and maintenance | ||||
Regulation of mRNA stability by proteins that bind AU-rich elements | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (3)
Components (7)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 3 | 4 | 95.5 | |||||
platelet count | 2 | 3 | 3 | 89.5 | |||||
mean corpuscular hemoglobin concentration | 3 | 3 | 3 | 85 | |||||
mean platelet volume | 3 | 1 | 3 | 84.3 | |||||
albumin:globulin ratio measurement | 1 | 1 | 1 | 79 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 95.5 | |||||
platelet count | 3 | 89.5 | |||||
mean corpuscular hemoglobin concentration | 3 | 85 | |||||
mean platelet volume | 3 | 84.3 | |||||
albumin:globulin ratio measurement | 1 | 79 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transportin 1 | VGNC:4207 | 461817 | |||||
Macaque | transportin 1 | 707195 | ||||||
Mouse | MGI:2681523 | 238799 | ||||||
Rat | RGD:1308372 | 309126 | ||||||
Dog | transportin 1 | VGNC:47694 | 478093 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transportin 1 | |||||
Macaque | transportin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transportin 1 | |||||
Publication Statistics
PubMed Score 64.14
PubMed score by year
PubTator Score 70.15
PubTator score by year
Related Publications
Text Mined References (91)
GeneRif Annotations (37)
Items per page:
0 of 0
PMID | Year | Title |
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