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Tbio
TNP1
Spermatid nuclear transition protein 1

Protein Summary
Description
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236979
  • ENSP00000236979
  • ENSG00000118245

Symbol
  • TP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
cellular component
0.63
co-expressed gene
0.61
cell line
0.51
virus perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.41   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.41   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
TNP2
Tbio
Novelty:  0.01170636
Score:  0.972
Data Source:  STRINGDB
PRM2
Tbio
Novelty:  0.0050028
Score:  0.899
Data Source:  STRINGDB
PRM1
Tbio
Novelty:  0.009665
Score:  0.82
Data Source:  STRINGDB
HIST3H3
Tbio
Novelty:  0.04915012
Score:  0.782
Data Source:  STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
Score:  0.776
Data Source:  STRINGDB
PRM3
Tdark
Novelty:  0.03634194
Score:  0.756
Data Source:  STRINGDB
NUPR1
Tbio
Novelty:  0.00934603
Score:  0.75
Data Source:  STRINGDB
HIST3H2A
Tbio
Novelty:  0.34036249
Score:  0.748
Data Source:  STRINGDB
KDM3A
Tchem
Family:  Epigenetic
Novelty:  0.0101705
Score:  0.744
Data Source:  STRINGDB
CENPA
Tbio
Novelty:  0.00154245
Score:  0.729
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
4
4
8
93.6
appendicular lean mass
3
2
3
73.8
creatinine measurement
3
3
3
57.3
hormone measurement
1
1
2
13.4
pulse pressure measurement
1
1
1
4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
8
93.6
appendicular lean mass
3
73.8
creatinine measurement
3
57.3
hormone measurement
2
13.4
pulse pressure measurement
1
4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transition protein 1
VGNC:2891
740418
Mouse
MGI:98784
21958
Rat
RGD:3884
24839
Dog
transition protein 1
VGNC:47693
100686780
Horse
transition protein 1
VGNC:24393
100630835
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transition protein 1
Mouse
Rat
Dog
transition protein 1
Horse
transition protein 1
Publication Statistics
PubMed Score 81.41
PubMed score by year
PubTator Score 182.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title