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Tbio
TNNT3
Troponin T, fast skeletal muscle

Protein Summary
Description
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skele ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278317
  • ENSP00000278317
  • ENSG00000130595
  • ENST00000344578
  • ENSP00000344870
  • ENST00000381558
  • ENSP00000370970
  • ENST00000381563
  • ENSP00000370975
  • ENST00000381579
  • ENSP00000370991
  • ENST00000381589
  • ENSP00000371001
  • ENST00000397301
  • ENSP00000380468
  • ENST00000641119
  • ENSP00000492914
  • ENST00000641787
  • ENSP00000493331

Symbol
  • TNTF
  • beta-TnTF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
PubMedID
0.65
molecular function
0.63
disease perturbation
0.62
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.41   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.41   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.999999955
p_ni:  2e-8
p_wrong:  2.4e-8
Data Source:  BioPlex
YTHDC2
Tbio
Family:  Enzyme
Novelty:  0.05211009
p_int:  0.99805709
p_ni:  0.00194291
Data Source:  BioPlex
GID4
Tbio
Novelty:  0.05252674
p_int:  0.97333126
p_ni:  0.02666874
Data Source:  BioPlex
MAEA
Tbio
Novelty:  0.00833813
p_int:  0.964585914
p_ni:  0.035414086
Data Source:  BioPlex
TXLNG
Tbio
Novelty:  0.08274423
p_int:  0.957211728
p_ni:  0.042739841
p_wrong:  0.000048431
Data Source:  BioPlex
PGPEP1
Tbio
Family:  Enzyme
Novelty:  0.00933029
p_int:  0.944099373
p_wrong:  0.055900626
Score:  0.543
Data Source:  BioPlex,STRINGDB
ARMC8
Tbio
Novelty:  0.06820746
p_int:  0.94179372
p_ni:  0.058206281
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.803287013
p_ni:  0.155898945
p_wrong:  0.040814042
Data Source:  BioPlex
TNNC2
Tbio
Novelty:  0.07759506
Score:  0.999
Data Source:  Reactome,STRINGDB
TNNI2
Tbio
Novelty:  0.02772952
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
4
4
5
93.4
systolic blood pressure
3
3
3
92.4
6
3
0
1.1
90.8
1
3
3
83.5
mean arterial pressure
3
3
3
83.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
5
93.4
systolic blood pressure
3
92.4
0
1.1
90.8
3
83.5
mean arterial pressure
3
83.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
troponin T3, fast skeletal type
746911
Macaque
troponin T3, fast skeletal type
704095
Mouse
MGI:109550
21957
Rat
RGD:3883
24838
Dog
troponin T3, fast skeletal type
VGNC:47692
475996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
troponin T3, fast skeletal type
Macaque
troponin T3, fast skeletal type
Mouse
Rat
Dog
troponin T3, fast skeletal type
Publication Statistics
PubMed Score 56.41
PubMed score by year
PubTator Score 18.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title