Tbio TNNT3 Troponin T, fast skeletal muscle

Protein Summary

Description

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P45378
• A8MQ76
• A8MSW1
• B3KPX3
• B7WP64
• B7ZL26
• B7ZVV9
• Q12975
• Q12976
• Q12977
• Q12978
• Q17RG9
• Q6FH29
• Q6N056
• Q86TH6
• TnTf

Gene Name

• TNNT3

Ensembl ID

• ENST00000278317
• ENSP00000278317
• ENSG00000130595
• ENST00000344578
• ENSP00000344870
• ENST00000381558
• ENSP00000370970
• ENST00000381563
• ENSP00000370975
• ENST00000381579
• ENSP00000370991
• ENST00000381589
• ENSP00000371001
• ENST00000397301
• ENSP00000380468
• ENST00000641119
• ENSP00000492914
• ENST00000641787
• ENSP00000493331

Symbol

• TNTF
• beta-TnTF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
PubMedID	0.65
molecular function	0.63
disease perturbation	0.62
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Troponin T, Fast Skeletal Muscle

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Troponin T, Fast Skeletal Muscle

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.41   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 263   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.41   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0