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Tbio
TNNI2
Troponin I, fast skeletal muscle

Protein Summary
Description
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252898
  • ENSP00000252898
  • ENSG00000130598
  • ENST00000381905
  • ENSP00000371330
  • ENST00000381906
  • ENSP00000371331
  • ENST00000381911
  • ENSP00000371336

Symbol
  • DA2B
  • FSSV
  • fsTnI
  • AMCD2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.59
disease perturbation
0.56
cellular component
0.53
tissue sample
0.53
transcription factor
0.5


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.1   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.1   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0