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Tbio
TNNC2
Troponin C, skeletal muscle

Protein Summary
Description
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372555
  • ENSP00000361636
  • ENSG00000101470
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.63
disease perturbation
0.49
tissue sample
0.47
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
MAML1
Tbio
Novelty:  0.01302751
p_int:  0.999999995
p_ni:  5e-9
Data Source:  BioPlex
NRIP1
Tbio
Novelty:  0.00551568
p_int:  0.999999949
p_ni:  2.9e-8
p_wrong:  2.3e-8
Data Source:  BioPlex
ZNF74
Tbio
Family:  TF
Novelty:  0.10554307
p_int:  0.999999826
p_ni:  1.68e-7
p_wrong:  6e-9
Data Source:  BioPlex
CLSPN
Tbio
Novelty:  0.01330727
p_int:  0.99999828
p_ni:  0.000001716
p_wrong:  5e-9
Data Source:  BioPlex
SEPHS2
Tdark
Family:  Enzyme
Novelty:  0.01657572
p_int:  0.999994691
p_ni:  0.000005305
p_wrong:  3e-9
Data Source:  BioPlex
ITPRID2
Tbio
Novelty:  0.07923791
p_int:  0.999983686
p_ni:  0.000016314
Data Source:  BioPlex
CHAMP1
Tbio
Novelty:  0.09520274
p_int:  0.99997882
p_ni:  0.000021171
p_wrong:  9e-9
Data Source:  BioPlex
POGZ
Tbio
Novelty:  0.03603188
p_int:  0.99997817
p_ni:  0.00002183
Data Source:  BioPlex
PML
Tbio
Novelty:  0.00285474
p_int:  0.999894145
p_ni:  0.000105855
Data Source:  BioPlex
ZBTB21
Tbio
Family:  TF
Novelty:  0.16032292
p_int:  0.999883056
p_ni:  0.000116944
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
7
18
99.2
triglyceride measurement
12
6
18
3.3
98.8
sleep duration
4
3
4
90.1
lipid measurement
1
1
1
80.3
mean platelet volume
2
1
2
79.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
99.2
triglyceride measurement
18
3.3
98.8
sleep duration
4
90.1
lipid measurement
1
80.3
mean platelet volume
2
79.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
troponin C2, fast skeletal type
VGNC:10013
741787
Macaque
troponin C2, fast skeletal type
717270
Mouse
MGI:98780
21925
Rat
RGD:1311973
296369
Dog
troponin C2, fast skeletal type
VGNC:47687
485899
Species
Name
OMA
EggNOG
Inparanoid
Chimp
troponin C2, fast skeletal type
Macaque
troponin C2, fast skeletal type
Mouse
Rat
Dog
troponin C2, fast skeletal type
Publication Statistics
PubMed Score 13.04
PubMed score by year
PubTator Score 6.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title