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Tbio
TNIP1
TNFAIP3-interacting protein 1

Protein Summary
Description
Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. Interacts with HIV-1 matrix protein and is packaged into virions and overexpression can inhibit viral replication. May regulate matrix nuclear localization, both nuclear import of PIC (Preintegration complex) and export of G ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315050
  • ENSP00000317891
  • ENSG00000145901
  • ENST00000518977
  • ENSP00000430971
  • ENST00000520931
  • ENSP00000429891
  • ENST00000521591
  • ENSP00000430760
  • ENST00000522226
  • ENSP00000428187
  • ENST00000523200
  • ENSP00000431105
  • ENST00000523338
  • ENSP00000428243
  • ENST00000524280
  • ENSP00000429912
  • ENST00000610535
  • ENSP00000483944
  • ENST00000610874
  • ENSP00000484665

Symbol
  • KIAA0113
  • NAF1
  • VAN
  • NAF1
  • ABIN-1
  • nip40-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
biological process
0.87
phenotype
0.86
transcription factor perturbation
0.8
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.47   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.47   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0