Tchem TNIK TRAF2 and NCK-interacting protein kinase

Protein Summary

Description

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

Uniprot Accession IDs

• Q9UKE5
• A7E2A3
• A8K4U1
• D3DNQ6
• O60298
• Q8WUY7
• Q9UKD8
• Q9UKD9
• Q9UKE0
• Q9UKE1
• Q9UKE2
• Q9UKE3
• Q9UKE4

Gene Name

• TNIK

Ensembl ID

• ENST00000284483
• ENSP00000284483
• ENSG00000154310
• ENST00000341852
• ENSP00000345352
• ENST00000357327
• ENSP00000349880
• ENST00000436636
• ENSP00000399511
• ENST00000460047
• ENSP00000418916
• ENST00000470834
• ENSP00000419990
• ENST00000475336
• ENSP00000418156
• ENST00000488470
• ENSP00000418378

Symbol

• KIAA0551
• MRT54

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
molecular function	0.96
small molecule	0.89
transcription factor binding site profile	0.89
interacting protein	0.85

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Ste Group / Ste20 Family / Msn Subfamily / Traf2 And Nck-interacting Protein Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.84   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 518   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.84   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 518   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 143

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2