TNFSF4
Tumor necrosis factor ligand superfamily member 4
Protein Summary
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
- ENST00000281834
- ENSP00000281834
- ENSG00000117586
- ENST00000367718
- ENSP00000356691
- TXGP1
- GP34
- CD252
- OX4OL
- TXGP1
- CD134L
- OX-40L
- TNLG2B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 0.75 | ||
disease | 0.72 | ||
gene perturbation | 0.66 | ||
tissue sample | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 401.12 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 663 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 401.12 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 663 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 44
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0