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Tbio
TNFSF4
Tumor necrosis factor ligand superfamily member 4

Protein Summary
Description
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281834
  • ENSP00000281834
  • ENSG00000117586
  • ENST00000367718
  • ENSP00000356691

Symbol
  • TXGP1
  • GP34
  • CD252
  • OX4OL
  • TXGP1
  • CD134L
  • OX-40L
  • TNLG2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.75
disease
0.72
gene perturbation
0.66
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.12   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 663   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.12   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 663   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0