Tclin TNFSF13B Tumor necrosis factor ligand superfamily member 13B

Protein Summary

Description

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q9Y275
• E0ADT7
• Q6FHD6
• Q7Z5J2

Gene Name

• TNFSF13B

Ensembl ID

• ENST00000375887
• ENSP00000365048
• ENSG00000102524
• ENST00000430559
• ENSP00000389540
• ENST00000542136
• ENSP00000445334

Symbol

• BAFF
• BLYS
• TALL1
• TNFSF20
• ZTNF4
• DTL
• BAFF
• BLYS
• CD257
• TALL1
• THANK
• ZTNF4
• TALL-1
• TNLG7A
• TNFSF20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
virus perturbation	0.98
disease	0.72
cell type or tissue	0.68
PubMedID	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2092.48   (req: < 5)

Gene RIFs: 454   (req: <= 3)

Antibodies: 1353   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2092.48   (req: >= 5)

Gene RIFs: 454   (req: > 3)

Antibodies: 1353   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1