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Tclin
TNFSF11
Tumor necrosis factor ligand superfamily member 11

Protein Summary
Description
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper os ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239849
  • ENSP00000239849
  • ENSG00000120659
  • ENST00000358545
  • ENSP00000351347
  • ENST00000398795
  • ENSP00000381775
  • ENST00000405262
  • ENSP00000384042
  • ENST00000544862
  • ENSP00000444913

Symbol
  • OPGL
  • RANKL
  • TRANCE
  • ODF
  • OPGL
  • sOdf
  • CD254
  • OPTB2
  • RANKL
  • TNLG6B
  • TRANCE
  • hRANKL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
0.88
PubMedID
0.87
gene perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7453.06   (req: < 5)
Gene RIFs: 541   (req: <= 3)
Antibodies: 1061   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7453.06   (req: >= 5)
Gene RIFs: 541   (req: > 3)
Antibodies: 1061   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1