Tbio TNFRSF9 Tumor necrosis factor receptor superfamily member 9

Protein Summary

Description

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q07011

Gene Name

• TNFRSF9

Ensembl ID

• ENST00000377507
• ENSP00000366729
• ENSG00000049249
• ENST00000615230
• ENSP00000478699

Symbol

• CD137
• ILA
• ILA
• 4-1BB
• CD137
• CDw137

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
gene perturbation	0.92
cell type or tissue	0.8
biological term	0.74
tissue	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 877.75   (req: < 5)

Gene RIFs: 116   (req: <= 3)

Antibodies: 994   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 877.75   (req: >= 5)

Gene RIFs: 116   (req: > 3)

Antibodies: 994   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0