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Tbio
TNFRSF25
Tumor necrosis factor receptor superfamily member 25

Protein Summary
Description
Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348333
  • ENSP00000314451
  • ENSG00000215788
  • ENST00000351748
  • ENSP00000326762
  • ENST00000351959
  • ENSP00000337713
  • ENST00000356876
  • ENSP00000349341
  • ENST00000377782
  • ENSP00000367013
  • ENST00000414040
  • ENSP00000404274
  • ENST00000485036
  • ENSP00000431554
  • ENST00000502588
  • ENSP00000423121
  • ENST00000502730
  • ENSP00000421976
  • ENST00000510563
  • ENSP00000424071

Symbol
  • APO3
  • DDR3
  • DR3
  • TNFRSF12
  • WSL
  • WSL1
  • DR3
  • TR3
  • DDR3
  • LARD
  • APO-3
  • TRAMP
  • WSL-1
  • GEF720
  • WSL-LR
  • PLEKHG5
  • TNFRSF12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
virus perturbation
0.85
PubMedID
0.74
tissue sample
0.66
disease
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2273.13   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 657   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2273.13   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 657   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0