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Tbio
TNFRSF19
Tumor necrosis factor receptor superfamily member 19

Protein Summary
Description
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248484
  • ENSP00000248484
  • ENSG00000127863
  • ENST00000382258
  • ENSP00000371693
  • ENST00000382263
  • ENSP00000371698
  • ENST00000403372
  • ENSP00000385408

Symbol
  • TAJ
  • TROY
  • TAJ
  • TROY
  • TRADE
  • TAJ-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
transcription factor perturbation
0.88
transcription factor
0.85
microRNA
0.82
small molecule perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.16   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.16   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
CST2
Tbio
Novelty:  0.02114441
p_int:  0.999811163
p_ni:  0.000179431
p_wrong:  0.000009406
Data Source:  BioPlex
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
p_int:  0.999703849
p_ni:  0.00029615
p_wrong:  1e-9
Data Source:  BioPlex
KLK10
Tbio
Family:  Enzyme
Novelty:  0.00899521
p_int:  0.999660545
p_ni:  0.000202602
p_wrong:  0.000136853
Data Source:  BioPlex
ZNF101
Tdark
Family:  TF
Novelty:  0.27004566
p_int:  0.999657828
p_ni:  0.000276398
p_wrong:  0.000065774
Score:  0.183
Data Source:  BioPlex,STRINGDB
CALML5
Tbio
Novelty:  0.03240679
p_int:  0.999583876
p_ni:  0.000416124
Data Source:  BioPlex
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.999300825
p_ni:  0.000699175
Data Source:  BioPlex
CRNN
Tbio
Novelty:  0.01648731
p_int:  0.999264311
p_ni:  0.000735689
Data Source:  BioPlex
FLG
Tbio
Novelty:  0.00072986
p_int:  0.998186294
p_ni:  0.001813706
Data Source:  BioPlex
CST1
Tbio
Novelty:  0.02399609
p_int:  0.997439055
p_ni:  0.000495852
p_wrong:  0.002065093
Data Source:  BioPlex
PHLDB3
Tdark
Novelty:  2.01921901
p_int:  0.997283202
p_ni:  0.002716798
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
79.8
2
2
0
1.2
40.3
bone density
1
1
1
33.1
1
1
0
1.2
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
79.8
0
1.2
40.3
bone density
1
33.1
0
1.2
11.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 19
VGNC:5124
452480
Macaque
TNF receptor superfamily member 19
707034
Mouse
MGI:1352474
29820
Rat
RGD:1564996
290300
Dog
TNF receptor superfamily member 19
VGNC:47661
486042
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 19
Macaque
TNF receptor superfamily member 19
Mouse
Rat
Dog
TNF receptor superfamily member 19
Publication Statistics
PubMed Score 78.16
PubMed score by year
PubTator Score 170.04
PubTator score by year
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Related Publications
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PMID
Year
Title