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Tbio
TNFRSF19
Tumor necrosis factor receptor superfamily member 19

Protein Summary
Description
Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248484
  • ENSP00000248484
  • ENSG00000127863
  • ENST00000382258
  • ENSP00000371693
  • ENST00000382263
  • ENSP00000371698
  • ENST00000403372
  • ENSP00000385408

Symbol
  • TAJ
  • TROY
  • TAJ
  • TROY
  • TRADE
  • TAJ-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
transcription factor perturbation
0.88
transcription factor
0.85
microRNA
0.82
small molecule perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.28   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 314   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.28   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 314   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0