Tbio TNFRSF13C Tumor necrosis factor receptor superfamily member 13C

Protein Summary

Description

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96RJ3

Gene Name

• TNFRSF13C

Ensembl ID

• ENST00000291232
• ENSP00000291232
• ENSG00000159958

Symbol

• BAFFR
• BR3
• BAFFR
• CD268
• CVID4
• BAFF-R
• BROMIX
• prolixin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.64
biological term	0.62
PubMedID	0.61
transcription factor	0.61
gene perturbation	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 665.93   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 569   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 665.93   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 569   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0