Tbio TNFRSF11A Tumor necrosis factor receptor superfamily member 11A

Protein Summary

Description

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q9Y6Q6
• I4EC36
• I4EC38
• I4EC39
• I7JE63
• N0GVH0
• Q59EP9

Gene Name

• TNFRSF11A

Ensembl ID

• ENST00000269485
• ENSP00000269485
• ENSG00000141655
• ENST00000586569
• ENSP00000465500
• ENST00000616710
• ENSP00000479567
• ENST00000617039
• ENSP00000482466

Symbol

• RANK
• FEO
• OFE
• ODFR
• OSTS
• PDB2
• RANK
• CD265
• OPTB7
• TRANCER
• LOH18CR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.97
biological term	0.92
virus perturbation	0.88
disease	0.75
phenotype	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2811.09   (req: < 5)

Gene RIFs: 230   (req: <= 3)

Antibodies: 701   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2811.09   (req: >= 5)

Gene RIFs: 230   (req: > 3)

Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0