TNFRSF11A
Tumor necrosis factor receptor superfamily member 11A
Protein Summary
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
- ENST00000269485
- ENSP00000269485
- ENSG00000141655
- ENST00000586569
- ENSP00000465500
- ENST00000616710
- ENSP00000479567
- ENST00000617039
- ENSP00000482466
- RANK
- FEO
- OFE
- ODFR
- OSTS
- PDB2
- RANK
- CD265
- OPTB7
- TRANCER
- LOH18CR1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.97 | ||
biological term | 0.92 | ||
virus perturbation | 0.88 | ||
disease | 0.75 | ||
phenotype | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1828.92 (req: < 5)
Gene RIFs: 187 (req: <= 3)
Antibodies: 701 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1828.92 (req: >= 5)
Gene RIFs: 187 (req: > 3)
Antibodies: 701 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (129)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (15)
Reactome (4)
KEGG (5)
PathwayCommons (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | ||||
Reactome | TNFR2 non-canonical NF-kB pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | ||||
TNFR2 non-canonical NF-kB pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (33)
Functions (5)
Components (4)
Processes (24)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (21)
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 2 | 6 | 91.6 | |||||
alkaline phosphatase measurement | 2 | 1 | 1 | 14.5 | 83.7 | ||||
2 | 2 | 0 | 1.5 | 76.8 | |||||
bone density | 5 | 2 | 7 | 70.5 | |||||
serum albumin measurement | 2 | 2 | 3 | 61.8 | |||||
Items per page:
1 – 5 of 21
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 6 | 91.6 | |||||
alkaline phosphatase measurement | 1 | 14.5 | 83.7 | ||||
0 | 1.5 | 76.8 | |||||
bone density | 7 | 70.5 | |||||
serum albumin measurement | 3 | 61.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | TNF receptor superfamily member 11a | VGNC:5213 | 468560 | |||||
Mouse | MGI:1314891 | 21934 | ||||||
Rat | RGD:1563614 | 498206 | ||||||
Dog | TNF receptor superfamily member 11a | VGNC:47654 | 483957 | |||||
Horse | TNF receptor superfamily member 11a | VGNC:50982 | 100056617 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | TNF receptor superfamily member 11a | |||||
Mouse | ||||||
Rat | ||||||
Dog | TNF receptor superfamily member 11a | |||||
Horse | TNF receptor superfamily member 11a | |||||
Publication Statistics
PubMed Score 1828.92
PubMed score by year
PubTator Score 234.64
PubTator score by year
Related Publications
Text Mined References (231)
GeneRif Annotations (187)
Items per page:
0 of 0
PMID | Year | Title |
|---|