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Tbio
TNFRSF10C
Tumor necrosis factor receptor superfamily member 10C

Protein Summary
Description
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356864
  • ENSP00000349324
  • ENSG00000173535

Symbol
  • DCR1
  • LIT
  • TRAILR3
  • TRID
  • LIT
  • DCR1
  • TRID
  • CD263
  • TRAILR3
  • TRAIL-R3
  • DCR1-TNFR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
tissue
0.59
cellular component
0.51
phenotype
0.51
cell type or tissue
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.62   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 647   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.62   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 647   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
SCAMP1
Tbio
Novelty:  0.03293648
p_int:  0.999999771
p_ni:  2.29e-7
Data Source:  BioPlex
SLC19A1
Tchem
Family:  Transporter
Novelty:  0.00536763
p_int:  0.999998016
p_ni:  3.31e-7
p_wrong:  0.000001652
Data Source:  BioPlex
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.999993796
p_ni:  0.000006204
p_wrong:  1e-9
Data Source:  BioPlex
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.999992636
p_ni:  0.000007364
Data Source:  BioPlex
ALG14
Tbio
Family:  Enzyme
Novelty:  0.09271278
p_int:  0.999982563
p_ni:  0.000013755
p_wrong:  0.000003682
Data Source:  BioPlex
SLC44A1
Tbio
Family:  Transporter
Novelty:  0.01499456
p_int:  0.999953664
p_ni:  0.0000166
p_wrong:  0.000029736
Data Source:  BioPlex
SLC6A6
Tbio
Family:  Transporter
Novelty:  0.00333868
p_int:  0.999943123
p_ni:  0.000053486
p_wrong:  0.00000339
Data Source:  BioPlex
LRRC4B
Tbio
Novelty:  0.21762254
p_int:  0.999910735
p_ni:  0.000065642
p_wrong:  0.000023623
Data Source:  BioPlex
SLC6A8
Tbio
Family:  Transporter
Novelty:  0.00332655
p_int:  0.999882496
p_ni:  0.000113953
p_wrong:  0.000003551
Data Source:  BioPlex
SLC22A23
Tbio
Family:  Transporter
Novelty:  0.23405744
p_int:  0.999865161
p_ni:  0.000020483
p_wrong:  0.000114356
Data Source:  BioPlex
Pathways (54)
Gene expression (Transcription) (R-HSA-74160)

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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 Regulates Transcription of Death Receptors and Ligands
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of Death Receptors and Ligands
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
2
3
91
TNF-related apoptosis-inducing ligand receptor 2 measurement
1
2
2
89.8
eosinophil count
3
2
3
87.6
myeloid white cell count
2
1
2
82.8
eosinophil percentage of leukocytes
2
2
2
82.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
3
91
TNF-related apoptosis-inducing ligand receptor 2 measurement
2
89.8
eosinophil count
3
87.6
myeloid white cell count
2
82.8
eosinophil percentage of leukocytes
2
82.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 10c
VGNC:50321
472713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 10c
Publication Statistics
PubMed Score 107.62
PubMed score by year
PubTator Score 113.83
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title