Tbio TNFRSF10B Tumor necrosis factor receptor superfamily member 10B

Protein Summary

Description

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• O14763
• O14720
• O15508
• O15517
• O15531
• Q6UXM8
• Q7Z360
• Q9BVE0

Gene Name

• TNFRSF10B

Ensembl ID

• ENST00000276431
• ENSP00000276431
• ENSG00000120889
• ENST00000347739
• ENSP00000317859

Symbol

• DR5
• KILLER
• TRAILR2
• TRICK2
• ZTNFR9
• DR5
• CD262
• KILLER
• TRICK2
• TRICKB
• ZTNFR9
• TRAILR2
• TRICK2A
• TRICK2B
• TRAIL-R2
• KILLER/DR5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.98
chemical	0.93
small molecule perturbation	0.84
biological process	0.78
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2348.69   (req: < 5)

Gene RIFs: 301   (req: <= 3)

Antibodies: 1085   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2348.69   (req: >= 5)

Gene RIFs: 301   (req: > 3)

Antibodies: 1085   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0