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Tchem
TNFRSF10A
Tumor necrosis factor receptor superfamily member 10A

Protein Summary
Description
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221132
  • ENSP00000221132
  • ENSG00000104689

Symbol
  • APO2
  • DR4
  • TRAILR1
  • DR4
  • APO2
  • CD261
  • TRAILR1
  • TRAILR-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.93
virus perturbation
0.88
chemical
0.79
biological process
0.74
disease
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3034.51   (req: < 5)
Gene RIFs: 172   (req: <= 3)
Antibodies: 1045   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3034.51   (req: >= 5)
Gene RIFs: 172   (req: > 3)
Antibodies: 1045   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (249)
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
p_int:  0.999999361
p_ni:  6.25e-7
p_wrong:  1.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
p_int:  0.999998975
p_ni:  6.99e-7
p_wrong:  3.27e-7
Data Source:  BioPlex
FADD
Tbio
Novelty:  0.00137968
p_int:  0.999995597
p_ni:  0.000003964
p_wrong:  4.39e-7
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
p_int:  0.999959782
p_ni:  0.000035298
p_wrong:  0.00000492
Data Source:  BioPlex
LSS
Tchem
Family:  Enzyme
Novelty:  0.00735187
p_int:  0.999892211
p_ni:  0.000107735
p_wrong:  5.4e-8
Score:  0.153
Data Source:  BioPlex,STRINGDB
ACVR1
Tchem
Family:  Kinase
Novelty:  0.00284646
p_int:  0.999864716
p_ni:  0.000077564
p_wrong:  0.00005772
Score:  0.663
Data Source:  BioPlex,STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
p_int:  0.999670654
p_ni:  0.000329339
p_wrong:  7e-9
Data Source:  BioPlex
IFNAR1
Tclin
Novelty:  0.00175488
p_int:  0.999623925
p_ni:  0.000376073
p_wrong:  2e-9
Score:  0.244
Data Source:  BioPlex,STRINGDB
TNFRSF10B
Tbio
Novelty:  0.00054433
p_int:  0.998387622
p_ni:  0.001612378
Score:  0.954
Data Source:  BioPlex,Reactome,STRINGDB
KCNT2
Tchem
Family:  IC
Novelty:  0.02412039
p_int:  0.995883315
p_ni:  0.004034113
p_wrong:  0.000082572
Score:  0.213
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (61)
Apoptosis (R-HSA-109581)

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Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Cell surface interactions at the vascular wall
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Cell surface interactions at the vascular wall
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
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10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
2
2
3
91
eosinophil count
3
2
3
87.6
myeloid white cell count
2
1
2
82.8
eosinophil percentage of leukocytes
2
2
2
82.2
neutrophil count
3
1
3
81
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
3
91
eosinophil count
3
87.6
myeloid white cell count
2
82.8
eosinophil percentage of leukocytes
2
82.2
neutrophil count
3
81
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 10a
VGNC:3001
743159
Macaque
TNF receptor superfamily member 10a
716826
Mouse
MGI:1341090
21933
Rat
Horse
tumor necrosis factor receptor superfamily member 10A
100057812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 10a
Macaque
TNF receptor superfamily member 10a
Mouse
Rat
Horse
tumor necrosis factor receptor superfamily member 10A
Publication Statistics
PubMed Score 3034.51
PubMed score by year
PubTator Score 520.22
PubTator score by year
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Related Publications
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PMID
Year
Title