TNFAIP6
Tumor necrosis factor-inducible gene 6 protein
Protein Summary
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
- ENST00000243347
- ENSP00000243347
- ENSG00000123610
- TSG6
- TSG6
- TSG-6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.98 | ||
gene perturbation | 0.94 | ||
virus perturbation | 0.92 | ||
small molecule perturbation | 0.61 | ||
biological term | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 287.04 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 287.04 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (137)
VCAN
Novelty: 0.00110986
p_int: 0.99999999
p_ni: 9e-9
p_wrong: 1e-9
Score: 0.291
Data Source: BioPlex,STRINGDB
ITIH2
Novelty: 0.04886358
p_int: 0.99995533
p_ni: 0.000044669
Score: 0.616
Data Source: BioPlex,STRINGDB
KCTD21
Novelty: 1.05252269
p_int: 0.999948151
p_ni: 0.000049994
p_wrong: 0.000001855
Data Source: BioPlex
RNF166
Novelty: 0.71460884
p_int: 0.999921137
p_ni: 0.000039366
p_wrong: 0.000039497
Data Source: BioPlex
WDR11
Novelty: 0.00560058
p_int: 0.99971272
p_ni: 0.000287226
p_wrong: 5.5e-8
Data Source: BioPlex
TBC1D23
Novelty: 0.18566729
p_int: 0.999379184
p_ni: 0.00061877
p_wrong: 0.000002045
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (1)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 2 | 55.1 | ||||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
2 | 55.1 | ||||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | TNF alpha induced protein 6 | VGNC:2890 | 460097 | |||||
Macaque | TNF alpha induced protein 6 | 694699 | ||||||
Mouse | MGI:1195266 | 21930 | ||||||
Rat | RGD:621359 | 84397 | ||||||
Dog | TNF alpha induced protein 6 | VGNC:47651 | 476147 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | TNF alpha induced protein 6 | |||||
Macaque | TNF alpha induced protein 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | TNF alpha induced protein 6 | |||||
Publication Statistics
PubMed Score 287.04
PubMed score by year
PubTator Score 123.39
PubTator score by year
Related Publications
Text Mined References (78)
GeneRif Annotations (59)
Items per page:
0 of 0
PMID | Year | Title |
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