You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNFAIP6
Tumor necrosis factor-inducible gene 6 protein

Protein Summary
Description
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. This gene can be induced by proinflammatory cytokines such as tumor necrosis factor alpha and interleukin-1. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.[provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243347
  • ENSP00000243347
  • ENSG00000123610

Symbol
  • TSG6
  • TSG6
  • TSG-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
gene perturbation
0.94
virus perturbation
0.92
small molecule perturbation
0.61
biological term
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.04   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287.04   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (137)
VCAN
Tbio
Novelty:  0.00110986
p_int:  0.99999999
p_ni:  9e-9
p_wrong:  1e-9
Score:  0.291
Data Source:  BioPlex,STRINGDB
FAM91A1
Tbio
Novelty:  0.76982657
p_int:  0.999997223
p_ni:  0.000002777
Data Source:  BioPlex
TXNDC16
Tdark
Novelty:  0.25365147
p_int:  0.999966884
p_ni:  0.000033116
Data Source:  BioPlex
ITIH2
Tbio
Novelty:  0.04886358
p_int:  0.99995533
p_ni:  0.000044669
Score:  0.616
Data Source:  BioPlex,STRINGDB
KCTD21
Tbio
Novelty:  1.05252269
p_int:  0.999948151
p_ni:  0.000049994
p_wrong:  0.000001855
Data Source:  BioPlex
RNF166
Tdark
Novelty:  0.71460884
p_int:  0.999921137
p_ni:  0.000039366
p_wrong:  0.000039497
Data Source:  BioPlex
KIF7
Tbio
Novelty:  0.02734596
p_int:  0.99991361
p_ni:  0.00008639
Data Source:  BioPlex
WDR11
Tbio
Novelty:  0.00560058
p_int:  0.99971272
p_ni:  0.000287226
p_wrong:  5.5e-8
Data Source:  BioPlex
C17orf75
Tbio
Novelty:  0.08706784
p_int:  0.999629571
p_ni:  0.000370429
Data Source:  BioPlex
TBC1D23
Tbio
Novelty:  0.18566729
p_int:  0.999379184
p_ni:  0.00061877
p_wrong:  0.000002045
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
55.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 6
VGNC:2890
460097
Macaque
TNF alpha induced protein 6
694699
Mouse
MGI:1195266
21930
Rat
RGD:621359
84397
Dog
TNF alpha induced protein 6
VGNC:47651
476147
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 6
Macaque
TNF alpha induced protein 6
Mouse
Rat
Dog
TNF alpha induced protein 6
Publication Statistics
PubMed Score 287.04
PubMed score by year
PubTator Score 123.39
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title