You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNFAIP1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226225
  • ENSP00000226225
  • ENSG00000109079
  • ENST00000544907
  • ENSP00000440749

Symbol
  • BACURD2
  • EDP1
  • B12
  • B61
  • EDP1
  • BTBD34
  • hBACURD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.97
histone modification site profile
0.89
transcription factor binding site profile
0.89
biological process
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.28   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.999999944
p_ni:  5.5e-8
p_wrong:  1e-9
Data Source:  BioPlex
KCTD13
Tbio
Novelty:  0.07000508
p_int:  0.99999991
p_ni:  9e-8
Score:  0.861
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999968082
p_ni:  0.000031918
Score:  0.677
Data Source:  BioPlex,STRINGDB
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999877838
p_ni:  0.000103146
p_wrong:  0.000019016
Score:  0.163
Data Source:  BioPlex,STRINGDB
UBXN1
Tbio
Novelty:  0.10675958
p_int:  0.999866886
p_ni:  0.000116193
p_wrong:  0.000016921
Score:  0.828
Data Source:  BioPlex,STRINGDB
USP25
Tchem
Family:  Enzyme
Novelty:  0.03671706
p_int:  0.999682922
p_ni:  0.000316705
p_wrong:  3.73e-7
Score:  0.817
Data Source:  BioPlex,STRINGDB
KCTD10
Tbio
Novelty:  0.10573929
p_int:  0.999604225
p_ni:  0.000395775
Score:  0.865
Data Source:  BioPlex,STRINGDB
NRP1
Tchem
Novelty:  0.00153628
p_int:  0.998269354
p_ni:  0.001720834
p_wrong:  0.000009811
Score:  0.313
Data Source:  BioPlex,STRINGDB
CLPSL1
Tdark
Family:  Enzyme
Novelty:  0.32091586
p_int:  0.996972596
p_ni:  0.002968478
p_wrong:  0.000058926
Score:  0.239
Data Source:  BioPlex,STRINGDB
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.816830378
p_ni:  0.183169622
Score:  0.71
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
4
9
92.8
osteoprotegerin measurement
2
1
2
86.6
interleukin-27 measurement
1
1
1
84.6
apolipoprotein B measurement
2
3
3
83
apolipoprotein A 1 measurement
2
2
2
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
92.8
osteoprotegerin measurement
2
86.6
interleukin-27 measurement
1
84.6
apolipoprotein B measurement
3
83
apolipoprotein A 1 measurement
2
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 1
VGNC:9726
468380
Macaque
TNF alpha induced protein 1
708102
Mouse
MGI:104961
21927
Rat
RGD:3877
287543
Dog
TNF alpha induced protein 1
VGNC:47648
491161
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 1
Macaque
TNF alpha induced protein 1
Mouse
Rat
Dog
TNF alpha induced protein 1
Publication Statistics
PubMed Score 32.28
PubMed score by year
PubTator Score 20.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title