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Tbio
TMX1
Thioredoxin-related transmembrane protein 1

Protein Summary
Description
May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000457354
  • ENSP00000393316
  • ENSG00000139921

Symbol
  • TMX
  • TXNDC
  • TXNDC1
  • TMX
  • TXNDC
  • PDIA11
  • TXNDC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor perturbation
0.96
virus perturbation
0.96
interacting protein
0.94
disease perturbation
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.1   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.1   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
p_int:  0.999979789
p_ni:  0.000020033
p_wrong:  1.78e-7
Score:  0.223
Data Source:  BioPlex,STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
p_int:  0.999974804
p_ni:  0.000025196
Score:  0.512
Data Source:  BioPlex,STRINGDB
EHD1
Tbio
Novelty:  0.00817602
p_int:  0.999903348
p_ni:  0.000096652
Score:  0.205
Data Source:  BioPlex,STRINGDB
CD320
Tbio
Novelty:  0.01978884
p_int:  0.999794811
p_ni:  0.000204223
p_wrong:  9.65e-7
Data Source:  BioPlex
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.999734872
p_ni:  0.000265128
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.999349793
p_ni:  0.000650202
p_wrong:  4e-9
Data Source:  BioPlex
IGSF8
Tbio
Novelty:  0.03016623
p_int:  0.999043495
p_ni:  0.000956505
Data Source:  BioPlex
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.998889598
p_ni:  0.001110402
Score:  0.171
Data Source:  BioPlex,STRINGDB
GRAMD1C
Tdark
Novelty:  0.46102163
p_int:  0.998781174
p_ni:  0.001218701
p_wrong:  1.25e-7
Score:  0.671
Data Source:  BioPlex,STRINGDB
GRAMD1B
Tbio
Novelty:  0.2994102
p_int:  0.998571252
p_ni:  0.001387243
p_wrong:  0.000041505
Score:  0.522
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin related transmembrane protein 1
VGNC:7453
467454
Macaque
thioredoxin related transmembrane protein 1
707057
Mouse
MGI:1919986
72736
Rat
RGD:1308455
362751
Dog
thioredoxin related transmembrane protein 1
VGNC:47643
610791
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin related transmembrane protein 1
Macaque
thioredoxin related transmembrane protein 1
Mouse
Rat
Dog
thioredoxin related transmembrane protein 1
Publication Statistics
PubMed Score 35.10
PubMed score by year
PubTator Score 29.21
PubTator score by year
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Related Publications
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PMID
Year
Title