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Tdark
TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319511
  • ENSP00000313214
  • ENSG00000168591
  • ENST00000357984
  • ENSP00000350672
  • ENST00000538716
  • ENSP00000444565
  • ENST00000587172
  • ENSP00000465153
  • ENST00000587989
  • ENSP00000466971
  • ENST00000589785
  • ENSP00000467364
  • ENST00000589856
  • ENSP00000467960
  • ENST00000590235
  • ENSP00000465015
  • ENST00000592825
  • ENSP00000466189

Symbol
  • FP2653
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
histone modification site profile
0.9
cell type or tissue
0.84
kinase perturbation
0.76
transcription factor
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.38   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.38   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.999999633
p_ni:  3.67e-7
Data Source:  BioPlex
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.999959643
p_ni:  0.000040357
Data Source:  BioPlex
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.999485088
p_ni:  0.000447
p_wrong:  0.000067912
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.99924404
p_ni:  0.000644739
p_wrong:  0.000111221
Data Source:  BioPlex
TMEM259
Tbio
Novelty:  0.10015777
p_int:  0.997564041
p_ni:  0.002435959
Score:  0.188
Data Source:  BioPlex,STRINGDB
DUSP3
Tchem
Family:  Enzyme
Novelty:  0.00518547
p_int:  0.996527658
p_ni:  0.000288482
p_wrong:  0.00318386
Score:  0.171
Data Source:  BioPlex,STRINGDB
ERLIN1
Tbio
Novelty:  0.06693859
p_int:  0.966467939
p_ni:  0.033532061
Score:  0.191
Data Source:  BioPlex,STRINGDB
TMUB1
Tbio
Novelty:  0.11851789
p_int:  0.88806098
p_ni:  0.111934356
p_wrong:  0.000004664
Score:  0.209
Data Source:  BioPlex,STRINGDB
ERLIN2
Tbio
Novelty:  0.04060163
p_int:  0.817164141
p_ni:  0.182835859
Score:  0.189
Data Source:  BioPlex,STRINGDB
THSD7A
Tbio
Novelty:  0.01515873
Score:  0.802
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
6
9
98.8
mean corpuscular volume
2
4
4
98.1
reticulocyte measurement
3
4
6
97.8
mean reticulocyte volume
1
4
4
96.5
heel bone mineral density
3
2
5
94
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
9
98.8
mean corpuscular volume
4
98.1
reticulocyte measurement
6
97.8
mean reticulocyte volume
4
96.5
heel bone mineral density
5
94
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane and ubiquitin like domain containing 2
VGNC:9725
739427
Macaque
transmembrane and ubiquitin like domain containing 2
714541
Mouse
MGI:1919303
72053
Rat
RGD:1304758
303567
Dog
transmembrane and ubiquitin like domain containing 2
VGNC:47642
607070
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane and ubiquitin like domain containing 2
Macaque
transmembrane and ubiquitin like domain containing 2
Mouse
Rat
Dog
transmembrane and ubiquitin like domain containing 2
Publication Statistics
PubMed Score 0.38
PubMed score by year
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Related Publications
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PMID
Year
Title