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Tbio
TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

Protein Summary
Description
Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as negative regulator of hepatocyte growth during regeneration (By similarity). iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297533
  • ENSP00000297533
  • ENSG00000164897
  • ENST00000392818
  • ENSP00000376565
  • ENST00000462940
  • ENSP00000417519
  • ENST00000476627
  • ENSP00000419214
  • ENST00000482202
  • ENSP00000418709

Symbol
  • C7orf21
  • DULP
  • HOPS
  • DULP
  • SB144
  • C7orf21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
tissue sample
0.65
cell line
0.57
tissue
0.55
transcription factor binding site profile
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
DUSP3
Tchem
Family:  Enzyme
Novelty:  0.00518547
p_int:  0.998157728
p_ni:  0.001842272
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.931064034
p_ni:  0.068935912
p_wrong:  5.3e-8
Data Source:  BioPlex
RIPK2
Tchem
Family:  Kinase
Novelty:  0.00574043
p_int:  0.911608524
p_ni:  0.088391469
p_wrong:  7e-9
Data Source:  BioPlex
TMUB2
Tdark
Novelty:  1.76302035
p_int:  0.88806098
p_ni:  0.111934356
p_wrong:  0.000004664
Score:  0.209
Data Source:  BioPlex,STRINGDB
RIC3
Tbio
Novelty:  0.0162412
p_int:  0.883995929
p_ni:  0.116004053
p_wrong:  1.9e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.852379563
p_ni:  0.147620399
p_wrong:  3.7e-8
Data Source:  BioPlex
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
p_int:  0.851854807
p_ni:  0.148145193
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.848787073
p_ni:  0.151208421
p_wrong:  0.000004506
Data Source:  BioPlex
KCNK16
Tbio
Family:  IC
Novelty:  0.09168043
p_int:  0.796270172
p_ni:  0.203725265
p_wrong:  0.000004564
Score:  0.241
Data Source:  BioPlex,STRINGDB
MCOLN2
Tchem
Family:  IC
Novelty:  0.05195244
p_int:  0.792615269
p_ni:  0.207382129
p_wrong:  0.000002601
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
3
4
94.2
Agents acting on the renin-angiotensin system use measurement
1
1
1
81.9
Diuretic use measurement
1
1
1
79
diastolic blood pressure
2
2
2
78.7
Calcium channel blocker use measurement
1
1
1
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
94.2
Agents acting on the renin-angiotensin system use measurement
1
81.9
Diuretic use measurement
1
79
diastolic blood pressure
2
78.7
Calcium channel blocker use measurement
1
77.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane and ubiquitin like domain containing 1
VGNC:8784
737498
Macaque
transmembrane and ubiquitin like domain containing 1
714606
Mouse
MGI:1923764
64295
Rat
RGD:735120
362301
Dog
transmembrane and ubiquitin like domain containing 1
VGNC:51832
610957
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane and ubiquitin like domain containing 1
Macaque
transmembrane and ubiquitin like domain containing 1
Mouse
Rat
Dog
transmembrane and ubiquitin like domain containing 1
Publication Statistics
PubMed Score 11.03
PubMed score by year
PubTator Score 2.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title