You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TMTC4
Transmembrane and TPR repeat-containing protein 4

Protein Summary
Description
This gene encodes a transmembrane protein that belongs to family of proteins containing an N-terminal transmembrane domain and a C-terminal tetratricopeptide repeat (TPR) domain. TPR domains mediate protein-protein interactions in various cellular processes, such as synaptic vesicle fusion, protein folding, and protein translocation. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328767
  • ENSP00000365409
  • ENSG00000125247
  • ENST00000342624
  • ENSP00000343871
  • ENST00000376234
  • ENSP00000365408
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
transcription factor perturbation
0.84
kinase perturbation
0.76
cell line
0.64
transcription factor binding site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.84   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.84   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.999679249
p_ni:  0.00032075
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.9994683
p_ni:  0.000531699
p_wrong:  1e-9
Score:  0.243
Data Source:  BioPlex,STRINGDB
PCDH12
Tbio
Novelty:  0.06268895
p_int:  0.999399341
p_ni:  0.000600657
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.999007
p_ni:  0.000992997
p_wrong:  3e-9
Data Source:  BioPlex
PCDHGC5
Tdark
Novelty:  0.39651826
p_int:  0.998800806
p_ni:  0.001199129
p_wrong:  6.5e-8
Data Source:  BioPlex
OS9
Tbio
Novelty:  0.01490339
p_int:  0.99801563
p_ni:  0.001984117
p_wrong:  2.54e-7
Data Source:  BioPlex
GORASP1
Tbio
Novelty:  0.02332405
p_int:  0.998001785
p_ni:  0.001997646
p_wrong:  5.69e-7
Data Source:  BioPlex
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
p_int:  0.995987684
p_ni:  0.004012308
p_wrong:  8e-9
Data Source:  BioPlex
NR4A1
Tchem
Family:  NR
Novelty:  0.00150135
p_int:  0.995380876
p_ni:  0.004619107
p_wrong:  1.8e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLC6A15
Tchem
Family:  Transporter
Novelty:  0.04011524
p_int:  0.995309998
p_ni:  0.004689985
p_wrong:  1.7e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
3
2
1
79.3
educational attainment
1
2
2
52
age at onset
1
1
0
6.3
49.7
refractive error
1
1
0
6.3
49.7
Myopia
1
1
0
6.3
49.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
79.3
educational attainment
2
52
age at onset
0
6.3
49.7
refractive error
0
6.3
49.7
Myopia
0
6.3
49.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921050
70551
Rat
RGD:1560183
290501
Dog
transmembrane and tetratricopeptide repeat containing 4
VGNC:47641
100855496
Horse
transmembrane and tetratricopeptide repeat containing 4
VGNC:24350
100062494
Cow
transmembrane and tetratricopeptide repeat containing 4
VGNC:36148
539972
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane and tetratricopeptide repeat containing 4
Horse
transmembrane and tetratricopeptide repeat containing 4
Cow
transmembrane and tetratricopeptide repeat containing 4
Publication Statistics
PubMed Score 2.84
PubMed score by year
PubTator Score 0.17
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title