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Tdark
TMPRSS11B
Transmembrane protease serine 11B

Protein Summary
Description
Serine protease.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332644
  • ENSP00000330475
  • ENSG00000185873

Symbol
  • HATL5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
virus perturbation
0.76
microRNA
0.54
cell line
0.52
phenotype
0.42


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.78   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.78   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.999849893
p_ni:  0.000150107
Data Source:  BioPlex
VKORC1
Tclin
Family:  Enzyme
Novelty:  0.00135838
p_int:  0.999767526
p_ni:  0.000006126
p_wrong:  0.000226348
Score:  0.237
Data Source:  BioPlex,STRINGDB
TMEM8A
Tdark
Novelty:  0.15724279
p_int:  0.998254955
p_ni:  0.001725271
p_wrong:  0.000019774
Data Source:  BioPlex
SEMA4F
Tbio
Novelty:  0.00574057
p_int:  0.9981968
p_ni:  0.001803197
p_wrong:  2e-9
Data Source:  BioPlex
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
p_int:  0.998177247
p_ni:  0.001769055
p_wrong:  0.000053698
Data Source:  BioPlex
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
p_int:  0.997583968
p_ni:  0.002407298
p_wrong:  0.000008734
Data Source:  BioPlex
GLRB
Tclin
Family:  IC
Novelty:  0.01721113
p_int:  0.996679222
p_ni:  0.002948357
p_wrong:  0.000372421
Data Source:  BioPlex
DCBLD2
Tbio
Novelty:  0.06514947
p_int:  0.995643089
p_ni:  0.004356724
p_wrong:  1.86e-7
Data Source:  BioPlex
DHFR2
Tbio
Family:  Enzyme
Novelty:  0.02374466
p_int:  0.984087652
p_ni:  0.015793971
p_wrong:  0.000118377
Data Source:  BioPlex
EDEM2
Tbio
Family:  Enzyme
Novelty:  0.1180208
p_int:  0.982169241
p_ni:  0.017830759
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 11B
VGNC:2055
461292
Mouse
MGI:2442893
319875
Rat
RGD:1303278
365265
Dog
transmembrane protease serine 11B-like protein
482175
Pig
transmembrane protease serine 11B
100513484
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane serine protease 11B
Mouse
Rat
Dog
transmembrane protease serine 11B-like protein
Pig
transmembrane protease serine 11B
Publication Statistics
PubMed Score 1.78
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
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PMID
Year
Title