Tbio TMOD4 Tropomodulin-4

Protein Summary

Description

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.

Uniprot Accession IDs

• Q9NZQ9
• B7Z6N9
• Q5JR83
• Q8WVL3
• Q9UKH2

Gene Name

• TMOD4

Ensembl ID

• ENST00000295314
• ENSP00000295314
• ENSG00000163157

Symbol

• SK-TMOD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.86
virus perturbation	0.72
gene perturbation	0.71
kinase perturbation	0.6
cell line	0.58

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Tropomodulin-4

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Tropomodulin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.22   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.22   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (107)

Explore Interacting Targets

1 – 10 of 107

• See Interactions on String-DB

LRRFIP1

Tbio

Novelty:  0.02584638

p_int:  0.999847692

p_ni:  0.000152308

Score:  0.589

Data Source:  BioPlex,STRINGDB

MTFR2

Tbio

Novelty:  0.20272025

p_int:  0.999110816

p_ni:  0.000032563

p_wrong:  0.000856621

Score:  0.163

Data Source:  BioPlex,STRINGDB

FECH

Tchem

Family:  Enzyme

Novelty:  0.00282289

p_int:  0.998007162

p_ni:  0.001992837

p_wrong:  1e-9

Data Source:  BioPlex

LRRFIP2

Tbio

Novelty:  0.15492934

p_int:  0.997908399

p_ni:  0.002091601

Score:  0.264

Data Source:  BioPlex,STRINGDB

FLII

Tbio

Novelty:  0.00200219

p_int:  0.996965429

p_ni:  0.003034571

Score:  0.571

Data Source:  BioPlex,STRINGDB

MYO5A

Tbio

Novelty:  0.00373224

p_int:  0.996901184

p_ni:  0.003098816

Score:  0.22

Data Source:  BioPlex,STRINGDB

ALAS1

Tclin

Family:  Enzyme

Novelty:  0.00965779

p_int:  0.996324839

p_ni:  0.003675147

p_wrong:  1.4e-8

Score:  0.159

Data Source:  BioPlex,STRINGDB

KAT14

Tbio

Novelty:  0.17168043

p_int:  0.99168325

p_ni:  0.00831675

Data Source:  BioPlex

GIT1

Tbio

Family:  Enzyme

Novelty:  0.01022741

p_int:  0.988397554

p_ni:  0.011602446

Score:  0.196

Data Source:  BioPlex,STRINGDB

NELFA

Tbio

Novelty:  0.09727823

p_int:  0.96144114

p_ni:  0.038514793

p_wrong:  0.000044068

Score:  0.187

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

Reactome (2)

Muscle contraction (R-HSA-397014)

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5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Muscle contraction	202 targets	R-HSA-397014
Reactome	Striated Muscle Contraction	34 targets	R-HSA-390522

Name	Explore in Pharos	Explore in Source
Muscle contraction	202 targets	R-HSA-397014
Striated Muscle Contraction	34 targets	R-HSA-390522

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (2)

Components (2)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
tropomyosin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
actin filament binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	1	1	0	33.3	78.9
myocardial infarction	EFO_0000612	1	1	0	100	76.6
monocyte percentage of leukocytes	EFO_0007989	1	1	1		60.5
vitamin D measurement	EFO_0004631	1	1	1		59
age at first sexual intercourse measurement	EFO_0009749	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
coronary artery disease	EFO_0001645	0	33.3	78.9
myocardial infarction	EFO_0000612	0	100	76.6
monocyte percentage of leukocytes	EFO_0007989	1		60.5
vitamin D measurement	EFO_0004631	1		59
age at first sexual intercourse measurement	EFO_0009749	1		33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Actin-binding
Alternative splicing
Complete proteome
Cytoplasm
Cytoskeleton
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
appendicular lean mass
BMI-adjusted hip circumference
body mass index
C-reactive protein measurement
calcium measurement
coronary artery disease
creatinine measurement
glomerular filtration rate
Ischemic stroke

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tropomodulin 4	VGNC:7009	457286
Macaque	tropomodulin 4		709732
Mouse	tropomodulin 4	MGI:1355285	50874
Rat	tropomodulin 4	RGD:1308940	295261
Dog	tropomodulin 4	VGNC:47626	483194

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tropomodulin 4
Macaque	tropomodulin 4
Mouse	tropomodulin 4
Rat	tropomodulin 4
Dog	tropomodulin 4

Publication Statistics

PubMed Score 82.22

PubMed score by year

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PubTator Score 11.75

PubTator score by year

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Related Publications

Text Mined References (9)

Items per page:

10

0 of 0

PMID	Year	Title