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Tbio
TMOD4
Tropomodulin-4

Protein Summary
Description
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295314
  • ENSP00000295314
  • ENSG00000163157

Symbol
  • SK-TMOD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.86
virus perturbation
0.72
gene perturbation
0.71
kinase perturbation
0.6
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
LRRFIP1
Tbio
Novelty:  0.02584638
p_int:  0.999847692
p_ni:  0.000152308
Score:  0.589
Data Source:  BioPlex,STRINGDB
MTFR2
Tbio
Novelty:  0.20272025
p_int:  0.999110816
p_ni:  0.000032563
p_wrong:  0.000856621
Score:  0.163
Data Source:  BioPlex,STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
p_int:  0.998007162
p_ni:  0.001992837
p_wrong:  1e-9
Data Source:  BioPlex
LRRFIP2
Tbio
Novelty:  0.15492934
p_int:  0.997908399
p_ni:  0.002091601
Score:  0.264
Data Source:  BioPlex,STRINGDB
FLII
Tbio
Novelty:  0.00200219
p_int:  0.996965429
p_ni:  0.003034571
Score:  0.571
Data Source:  BioPlex,STRINGDB
MYO5A
Tbio
Novelty:  0.00373224
p_int:  0.996901184
p_ni:  0.003098816
Score:  0.22
Data Source:  BioPlex,STRINGDB
ALAS1
Tclin
Family:  Enzyme
Novelty:  0.00965779
p_int:  0.996324839
p_ni:  0.003675147
p_wrong:  1.4e-8
Score:  0.159
Data Source:  BioPlex,STRINGDB
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.99168325
p_ni:  0.00831675
Data Source:  BioPlex
GIT1
Tbio
Family:  Enzyme
Novelty:  0.01022741
p_int:  0.988397554
p_ni:  0.011602446
Score:  0.196
Data Source:  BioPlex,STRINGDB
NELFA
Tbio
Novelty:  0.09727823
p_int:  0.96144114
p_ni:  0.038514793
p_wrong:  0.000044068
Score:  0.187
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
33.3
78.9
1
1
0
100
76.6
monocyte percentage of leukocytes
1
1
1
60.5
vitamin D measurement
1
1
1
59
age at first sexual intercourse measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
33.3
78.9
0
100
76.6
monocyte percentage of leukocytes
1
60.5
vitamin D measurement
1
59
age at first sexual intercourse measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tropomodulin 4
VGNC:7009
457286
Macaque
tropomodulin 4
709732
Mouse
MGI:1355285
50874
Rat
RGD:1308940
295261
Dog
tropomodulin 4
VGNC:47626
483194
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tropomodulin 4
Macaque
tropomodulin 4
Mouse
Rat
Dog
tropomodulin 4
Publication Statistics
PubMed Score 82.22
PubMed score by year
PubTator Score 11.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title