Tbio TMOD4 Tropomodulin-4

Protein Summary

Description

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.

Uniprot Accession IDs

• Q9NZQ9
• B7Z6N9
• Q5JR83
• Q8WVL3
• Q9UKH2

Gene Name

• TMOD4

Ensembl ID

• ENST00000295314
• ENSP00000295314
• ENSG00000163157

Symbol

• SK-TMOD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.86
virus perturbation	0.72
gene perturbation	0.71
kinase perturbation	0.6
cell line	0.58

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Tropomodulin-4

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Tropomodulin-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.94   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.94   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0