Protein Summary
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton.
- ENST00000295314
- ENSP00000295314
- ENSG00000163157
- SK-TMOD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.86 | ||
virus perturbation | 0.72 | ||
gene perturbation | 0.71 | ||
kinase perturbation | 0.6 | ||
cell line | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.22 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 150 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.22 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 150 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (107)
LRRFIP1
Novelty: 0.02584638
p_int: 0.999847692
p_ni: 0.000152308
Score: 0.589
Data Source: BioPlex,STRINGDB
MTFR2
Novelty: 0.20272025
p_int: 0.999110816
p_ni: 0.000032563
p_wrong: 0.000856621
Score: 0.163
Data Source: BioPlex,STRINGDB
FECH
Family: Enzyme
Novelty: 0.00282289
p_int: 0.998007162
p_ni: 0.001992837
p_wrong: 1e-9
Data Source: BioPlex
LRRFIP2
Novelty: 0.15492934
p_int: 0.997908399
p_ni: 0.002091601
Score: 0.264
Data Source: BioPlex,STRINGDB
FLII
Novelty: 0.00200219
p_int: 0.996965429
p_ni: 0.003034571
Score: 0.571
Data Source: BioPlex,STRINGDB
MYO5A
Novelty: 0.00373224
p_int: 0.996901184
p_ni: 0.003098816
Score: 0.22
Data Source: BioPlex,STRINGDB
ALAS1
Family: Enzyme
Novelty: 0.00965779
p_int: 0.996324839
p_ni: 0.003675147
p_wrong: 1.4e-8
Score: 0.159
Data Source: BioPlex,STRINGDB
GIT1
Family: Enzyme
Novelty: 0.01022741
p_int: 0.988397554
p_ni: 0.011602446
Score: 0.196
Data Source: BioPlex,STRINGDB
NELFA
Novelty: 0.09727823
p_int: 0.96144114
p_ni: 0.038514793
p_wrong: 0.000044068
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
Reactome (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Muscle contraction | ||||
Reactome | Striated Muscle Contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Muscle contraction | ||||
Striated Muscle Contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (2)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
1 | 1 | 0 | 33.3 | 78.9 | |||||
1 | 1 | 0 | 100 | 76.6 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 60.5 | |||||
vitamin D measurement | 1 | 1 | 1 | 59 | |||||
age at first sexual intercourse measurement | 1 | 1 | 1 | 33.1 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 33.3 | 78.9 | |||||
0 | 100 | 76.6 | |||||
monocyte percentage of leukocytes | 1 | 60.5 | |||||
vitamin D measurement | 1 | 59 | |||||
age at first sexual intercourse measurement | 1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | tropomodulin 4 | VGNC:7009 | 457286 | |||||
Macaque | tropomodulin 4 | 709732 | ||||||
Mouse | MGI:1355285 | 50874 | ||||||
Rat | RGD:1308940 | 295261 | ||||||
Dog | tropomodulin 4 | VGNC:47626 | 483194 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | tropomodulin 4 | |||||
Macaque | tropomodulin 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | tropomodulin 4 | |||||
Publication Statistics
PubMed Score 82.22
PubMed score by year
PubTator Score 11.75
PubTator score by year
Related Publications
Text Mined References (9)
Items per page:
0 of 0
PMID | Year | Title |
---|